Evidence map›Paper›PMID 36341417›Full record

ArticleFrontiers in immunology2022

Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis.

Daisuke Yamada, Simon Vu, Xuesong Wu, Zhenrui Shi, Desiree Morris, Joshua D Bloomstein, Mindy Huynh, Jie Zheng, Samuel T Hwang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Aberrant Enhancer Regulation, Phase Separation, and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2025
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Daisuke YamadaDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Simon VuDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.
Xuesong WuDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Zhenrui ShiDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Desiree MorrisKirk Kerkorian School of Medicine at University of Nevada, Las Vegas, Las, Vegas, NV, United States.
Joshua D BloomsteinDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Mindy HuynhDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Jie ZhengDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.
Samuel T HwangDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
University of California, Davis · USSun Yat-sen University · CNUniversity of Nevada, Las Vegas · US

Funding

Deep-learning methods based computational modelingR01NS128180 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Juan Du, VLADIMIR M YAROV-YAROVOY · 2022 to 2026
$3.3M
NINDS NIH HHS R01 NS128180
6 · The paper itself

Abstract

Transient receptor potential melastatin 4 (TRPM4) is a Ca

Indexed as

EczemaPsoriasisTRPM Cation ChannelsAnimalsGain of Function MutationHumansImiquimodMiceSkinImiquimodTRPM4 protein, humanTRPM4 protein, mouseTRPM Cation Channelsdendritic cellglibenclamideimiquimod (IMQ)keratinocytemouse modelprogressive symmetric erythrokeratodermiapsoriasisTRPM4

Identifiers

PMID36341417
PMCPMC9632438
OpenAlexW4306878911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.