Evidence map›Paper›PMID 36341414›Full record

ArticleFrontiers in immunology2022

The rectal mucosal immune environment and HIV susceptibility among young men who have sex with men.

Cassie G Ackerley, S Abigail Smith, Phillip M Murray, Praveen K Amancha, Robert A Arthur, Zhengyi Zhu, Ann Chahroudi, Rama R Amara, Yi-Juan Hu, Colleen F Kelley

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cassie G AckerleyThe Hope Clinic of the Emory Vaccine Research Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA, United States.
S Abigail SmithThe Hope Clinic of the Emory Vaccine Research Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA, United States.
Phillip M MurrayThe Hope Clinic of the Emory Vaccine Research Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA, United States.
Praveen K AmanchaThe Hope Clinic of the Emory Vaccine Research Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA, United States.
Robert A ArthurEmory Integrated Computational Core, Emory University, Atlanta, GA, United States.
Zhengyi ZhuDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Rama R AmaraEmory National Primate Research Center, Emory University, Atlanta, GA, United States.
Yi-Juan HuDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Colleen F KelleyThe Hope Clinic of the Emory Vaccine Research Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA, United States.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Emory University BIRCWH ProgramK12HD085850 · NICHD · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, STERK, CLAIRE E · 2015 to 2023
$4.4M
Research Training in Translational Gastroenterology and HepatologyT32DK108735 · NIDDK · EMORY UNIVERSITY · PI SUBRA KUGATHASAN · 2016 to 2026
$2.6M
Understanding Rectal HIV transmission among At-risk MSM: Age, Intercourse, and Mucosal InjurR01AI128799 · NIAID · EMORY UNIVERSITY · PI KELLEY, COLLEEN F · 2017 to 2020
$2.4M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI128799NICHD NIH HHS K12 HD085850NIDDK NIH HHS T32 DK108735
6 · The paper itself

Abstract

Young men who have sex with men (YMSM) represent a particularly high-risk group for HIV acquisition in the US, despite similarly reported rates of sexual activity as older, adult MSM (AMSM). Increased rates of HIV infection among YMSM compared to AMSM could be partially attributable to differences within the rectal mucosal (RM) immune environment associated with earlier sexual debut and less lifetime exposure to receptive anal intercourse. Using an

Indexed as

HIV InfectionsSexual and Gender MinoritiesAdultHomosexuality, MaleHumansMaleMucous MembraneSexual BehaviorHIV transmissionmicrobiomemucosal immunityrectal mucosaviral replicationYMSM

Identifiers

PMID36341414
PMCPMC9631201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.