Evidence map›Paper›PMID 36341403›Full record

ArticleFrontiers in immunology2022

Dietary phytate primes epithelial antibacterial immunity in the intestine.

Seika Hashimoto-Hill, Luisa Colapietro, Vivienne Woo, Simona Antonacci, Jordan Whitt, Laura Engleman, Theresa Alenghat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Seika Hashimoto-HillDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Luisa ColapietroDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Vivienne WooDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Simona AntonacciDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Jordan WhittDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Laura EnglemanDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Theresa AlenghatDivision of Immunobiology, and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, United States.
University of Cincinnati · USCincinnati Children's Hospital Medical Center · US

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI James M Wells · 2007 to 2026
$24.4M
Host integration of commensal and pathogenic bacterial-derived signalsR01DK116868 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2018 to 2026
$4.1M
Epigenomic control of antimicrobial immunity in the intestineR01DK114123 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ALENGHAT, THERESA · 2018 to 2022
$1.8M
Commensal bacterial metabolism of dietary phytate in host defenseK08DK134884 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Seika Hashimoto-Hill · 2023 to 2026
$622k
NIDDK NIH HHS K08 DK134884NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK114123NIDDK NIH HHS R01 DK116868
6 · The paper itself

Abstract

Although diet has long been associated with susceptibility to infection, the dietary components that regulate host defense remain poorly understood. Here, we demonstrate that consuming rice bran decreases susceptibility to intestinal infection with

Indexed as

Enterobacteriaceae InfectionsPhytic AcidAnimalsAnti-Bacterial AgentsDietEscherichia coliHumansIntestinesMammalsMiceAnti-Bacterial AgentsPhytic Aciddietinnate immunityintestinemetabolitemicrobiota

Identifiers

PMID36341403
PMCPMC9627201
OpenAlexW4306764929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.