Evidence map›Paper›PMID 36341330›Full record

ArticleFrontiers in immunology2022

Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus.

Lauren K Heine, Abby D Benninghoff, Elizabeth A Ross, Lichchavi D Rajasinghe, James G Wagner, Ryan P Lewandowski, Alexa L Richardson, Quan-Zhen Li, John P Buchweitz, Justin Zyskowski and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Lauren K HeineDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States.
Abby D BenninghoffDepartment of Animal, Dairy and Veterinary Sciences, School of Veterinary Medicine, Utah State University, Logan, UT, United States.
Elizabeth A RossDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
Lichchavi D RajasingheDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
James G WagnerInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Ryan P LewandowskiDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States.
Alexa L RichardsonDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
Quan-Zhen LiDepartment of Immunology and Internal Medicine, Institute fo Innovations in Medical Technology (IIMT) Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, United States.
John P BuchweitzInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Justin ZyskowskiToxicology Section, Michigan State University Veterinary Diagnostic Laboratory, Lansing, MI, United States.
Ashleigh N TindleDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States.
Anna E SkedelDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States.
Nicholas J ChargoDepartment of Physiology, Michigan State University, East Lansing, MI, United States.
Laura R McCabeDepartment of Physiology, Michigan State University, East Lansing, MI, United States.
Jack R HarkemaDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States.
James J PestkaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Michigan State University · USThe University of Texas Southwestern Medical Center · USUtah State University · US

Funding

MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.R01ES027353 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2017 to 2026
$4.8M
NIEHS NIH HHS R01 ES027353NIEHS NIH HHS T32 ES007255
6 · The paper itself

Abstract

Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO

Indexed as

Autoimmune DiseasesGlomerulonephritisAnimalsAutoimmunityDisease Models, AnimalFemaleGlucocorticoidsHumansInfant, NewbornMicePrednisoneSilicon DioxideGlucocorticoidsPrednisoneSilicon Dioxideautoantibodycrystalline silicaectopic lymphoid tissuekidneylungmuscle wasting (atrophy)systemic lupus erythematosus

Identifiers

PMID36341330
PMCPMC9627297
OpenAlexW4306843395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.