Evidence map›Paper›PMID 36341308›Full record

ArticleChromatographia2022

Easily Operable Quantification Method of 21 Plant-Derived Alkaloids in Human Serum by Automatic Sample Preparation and Liquid Chromatography-Tandem Mass Spectrometry.

Masaru Taniguchi, Naoki Takamura, Tsutomu Watanabe, Reiko Ishimaru, Satoshi Chinaka, Akihiro Miki, Hitoshi Miyazaki, Hitoshi Tsuchihashi, Kei Zaitsu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chromatographia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Masaru TaniguchiNagoya City Public Health Research Institute, 2266-132 Anagahora, Shimoshidami, Moriyama-Ku, Nagoya, 463-8585 Japan.ORCID 0000-0002-4472-0400
Naoki TakamuraShimadzu Engineering Inc., 1 Nishinokyo Kuwabara-Cho, Nakagyo-Ku, Kyoto, 604-8511 Japan.
Tsutomu WatanabeShimadzu Engineering Inc., 1 Nishinokyo Kuwabara-Cho, Nakagyo-Ku, Kyoto, 604-8511 Japan.
Reiko IshimaruForensic Science Laboratory, Ishikawa Prefectural Police Headquarters, 1-1 Kuratsuki, Kanazawa, Ishikawa 920-8553 Japan.
Satoshi ChinakaForensic Science Laboratory, Ishikawa Prefectural Police Headquarters, 1-1 Kuratsuki, Kanazawa, Ishikawa 920-8553 Japan.
Akihiro MikiForensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-Ku, Osaka, 541-0053 Japan.
Hitoshi MiyazakiNagoya City Public Health Research Institute, 2266-132 Anagahora, Shimoshidami, Moriyama-Ku, Nagoya, 463-8585 Japan.
Hitoshi TsuchihashiDepartment of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550 Japan.
Kei ZaitsuMultimodal Informatics and Wide-Data Analytics Laboratory, Department of Computational Systems Biology, Faculty of Biology-Oriented Science and Technology, Kindai University, 930 Nishi Mitani, Kinokawa, Wakayama, 649-6493 Japan.ORCID 0000-0001-7613-5735
Ishikawa Prefectural Police · JPNagoya Industrial Science Research Institute · JPShimadzu (Japan) · JPKindai University · JPNagoya University · JPOsaka Prefectural Police Department · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we developed an easily operable quantification method for 21 plant-derived alkaloids in human serum by automatic sample preparation and liquid chromatography-tandem mass spectrometry. We designed to perform parallel sample preparation by a developed apparatus, which increased sample throughput. We conducted an automatic sample preparation through de-proteinization with 0.1% formic acid in methanol and achieved recovery rates of 89-107% (2.0-14% RSD) for all targeted analytes, demonstrating its high repeatability. The method validation results were satisfactory as follows: the linearity ( Supplementary Information: The online version contains supplementary material available at 10.1007/s10337-022-04212-5.

Indexed as

Automatic sample preparationFood poisoningHuman serumLC/MS/MSPlant-derived alkaloidsQuantification

Identifiers

PMID36341308
PMCPMC9617228
OpenAlexW4307820773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.