Evidence map›Paper›PMID 36341301›Full record

ReviewNanoscale advances2022

Transformable nanoparticles to bypass biological barriers in cancer treatment.

Mythili Ramachandran, Zhao Ma, Kai Lin, Cristabelle De Souza, Yuanpei Li

Abstract readReview
In one paragraph

Review in Nanoscale advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Preparation of DOX-TPP/HA-ss-OA Nanoparticles, Investigation of Drug Release BehaviorCombinatorial chemistry & high throughput screening · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mythili RamachandranDepartment of Biochemistry and Molecular Medicine, University of California-Davis USA lypli@ucdavis.edu.ORCID https://orcid.org/0000-0001-8529-1545
Zhao MaDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University Jinan Shandong China.
Kai LinCollege of Food Science and Engineering, Ocean University of China Qingdao China.
Cristabelle De SouzaDepartment of Pathology and Stem Cell Research, Stanford University USA.
Yuanpei LiDepartment of Biochemistry and Molecular Medicine, University of California-Davis USA lypli@ucdavis.edu.ORCID https://orcid.org/0000-0002-4015-646X

Funding

Nano-Therapeutic Approaches for Oncogenic Herpesvirus-Mediated MalignanciesR01CA232845 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZUMIYA, YOSHIHIRO, LI, YUANPEI · 2018 to 2022
$3.2M
Tumor-penetrating nano-theranostics for image-guided interventions in spontaneous feline head and neck cancerR01DE029237 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LI, YUANPEI · 2020 to 2024
$2.9M
A “STICK” theranostic nanoplatform for image-guided drug delivery to brain malignanciesR01EB033677 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LI, YUANPEI · 2022 to 2025
$2.4M
Stimuli-responsive crosslinked theranostics against advanced prostate cancerR01CA199668 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LI, YUANPEI · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA199668NCI NIH HHS R01 CA232845NIBIB NIH HHS R01 EB033677NIDCR NIH HHS R01 DE029237
6 · The paper itself

Abstract

Nanomedicine based drug delivery platforms provide an interesting avenue to explore for the future of cancer treatment. Here we discuss the barriers for drug delivery in cancer therapeutics and how nanomaterials have been designed to bypass these blockades through stimuli responsive transformation in the most recent update. Nanomaterials that address the challenges of each step provide a promising solution for new cancer therapeutics.

Identifiers

PMID36341301
PMCPMC9595105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.