Evidence map›Paper›PMID 36341287›Full record

ArticleNanoscale advances2022

Highly biocompatible chlorin e6-poly(dopamine) core-shell nanoparticles for enhanced cancer phototherapy.

Shilin Chen, Yihang Jiang, Miaozhaung Fan, Xinmeng Zhang, Ying Zhang, Ting Chen, Chengbin Yang, Wing-Cheung Law, Zhourui Xu, Gaixia Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shilin ChenGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.
Yihang JiangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.ORCID https://orcid.org/0000-0001-8992-4338
Miaozhaung FanGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.
Xinmeng ZhangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.
Ying ZhangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.
Ting ChenDepartment of Industrial and Systems Engineering, The Hong Kong Polytechnic University Hong Kong roy.law@polyu.edu.hk.
Chengbin YangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.
Wing-Cheung LawDepartment of Industrial and Systems Engineering, The Hong Kong Polytechnic University Hong Kong roy.law@polyu.edu.hk.ORCID https://orcid.org/0000-0003-3855-6170
Zhourui XuGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.ORCID https://orcid.org/0000-0002-2462-9909
Gaixia XuGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060 China xuzhouray@szu.edu.cn xugaixia@szu.edu.cn.ORCID https://orcid.org/0000-0001-9311-0978
Shenzhen University Health Science Center · CNHong Kong Polytechnic University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a life-threatening disease worldwide. Although several approaches, such as surgery, chemotherapy, and radiotherapy, have been proven effective for many patients in clinics, they usually suffer from drug resistance, severe toxic-side effects, patient discomfort, and sometimes, unsatisfactory efficacies. In recent years, phototherapy, as a less invasive but effective therapeutic method, has brought hope for cancer treatment. However, most reported photo-therapeutic agents are constructed using complex components with non-negligible toxicity risk, thus retarding the start of their clinical trials. To address this issue, herein, biocompatible photothermal/photodynamic dual-mode therapeutic nanoparticles (CBP NPs) were successfully designed and constructed based on the Food and Drug Administration (FDA)-approved ingredients, chlorin e6 (Ce6) and poly(dopamine) (PDA). Upon light irradiation, hyperthermia was induced and reactive oxygen species (ROS) were generated simultaneously by CBP NPs, contributing to synergistic phototherapy toward cancer. The

Identifiers

PMID36341287
PMCPMC9595193
OpenAlexW4296126405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.