ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2022
Relative Hypoglycemia is Associated with Delirium in Critically Ill Patients with Diabetes: A Cohort Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association between hemoglobin glycation index and delirium after gastric surgery: Based upon the MIMIC-IV.Medicine · 2026Article
- Association of intraoperative dexamethasone administration with postoperative delirium and the role of hyperglycaemia: a retrospective cohort study.EClinicalMedicine · 2026Article
- Diabetes and postoperative cognitive dysfunction and delirium in adults: mechanisms, biomarkers, and clinical management.Frontiers in endocrinology · 2026Review
- Withdrawal-Induced Delirium in Opioid Dependence: A Systematic Review.Brain sciences · 2025Review
- The Association Between Frequency of Fingertip Blood Glucose Measurement and Delirium in Intensive Care Unit Patients: A Retrospective Study Based on the MIMIC-IV Database.Nursing in critical care · 2025Article
- Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- The Role of Stress Hyperglycemia on Delirium Onset.Journal of clinical medicine · 2025Review
- Exploring the correlation between corrective glucose treatment and long-term patient outcomes: a SHINE secondary analysis.Frontiers in neurology · 2025Article
- Continuous Glucose Monitoring in Older Adults: What We Know and What We Have Yet to Learn.Journal of diabetes science and technology · 2024Review
- Association between Preoperative Glucose Dysregulation and Delirium after Non-Cardiac Surgery.Journal of clinical medicine · 2024Article
- Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan.Clinical drug investigation · 2024Article
- Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database.Frontiers in endocrinology · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Critically ill patients with premorbid diabetes can suffer from relative hypoglycemia (RHG), falling below the normal blood glucose (BG) target. However, these events have not been well defined or studied. In the present study, we aimed to explore the incidence and clinical significance of RHG events in critically ill patients with diabetes. Patients and methods: Patients with a history of diabetes who stayed in the intensive care unit (ICU) for more than three days with at least 12 BG recordings were retrospectively included in the study. A BG level > 30% below the estimated average according to patient hemoglobin A1c measured at admission was defined as a single RHG event. Outcomes were compared between patients with and those without RHG events. Results: In total, 113 patients were included in the final analysis. RHG was detected in 73 patients (64.6%). Those who experienced RHG events had a significantly higher incidence of ICU delirium. They also had a higher risk of 28-day mortality, but this was not statistically significant. However, patients with a higher frequency of RHG events did have a significantly higher risk of overall mortality (57.1% for more than four events vs 15.4% for three to four events, P=0.006 and 15.1% for one to two events, P=0.003). Conclusion: In conclusion, RHG is a common finding in critically ill patients with diabetes and is associated with mortality and the occurrence of delirium.
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