Evidence map›Paper›PMID 36341217›Full record

ReviewJACC. Asia2021

Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region.

Hayato Tada, Khung Keong Yeo, Jian-Jun Li, Kathryn Tan, Junya Ako, Rungroj Krittayaphong, Ru San Tan, Philip E Aylward, Carolyn S P Lam, Sang Hong Baek and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Asia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hayato TadaDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Khung Keong YeoNational Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences, Singapore.
Jian-Jun LiState Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Kathryn TanDepartment of Medicine, University of Hong Kong, Hong Kong.
Junya AkoKitasato University, Sagamihara, Japan.
Rungroj KrittayaphongDivision of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Ru San TanNational Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences, Singapore.
Philip E AylwardSouth Australian Health and Medical Research Institute and Flinders University, Adelaide, South Australia, Australia.
Carolyn S P LamNational Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences, Singapore.
Sang Hong BaekSeoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jamshed DalalKokilaben Hospital, Mumbai, India.
Alan FongDepartment of Cardiology, Sarawak Heart Centre, and Clinical Research Centre, Sarawak General Hospital, Kuching, Malaysia.
Yi-Heng LiNational Cheng Kung University Hospital, Tainan, Taiwan.
Richard C O'BrienUniversity of Melbourne and Austin Health, Melbourne, Victoria, Australia.
Si Ya Natalie KohNational Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences, Singapore.
Daniel J SchererSouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Vernon KangSingapore Heart Foundation, Singapore.
Adam J NelsonVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Julie ButtersVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Stephen J NichollsVictorian Heart Institute, Monash University, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into "scores" can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.

Indexed as

ASCVD, atherosclerotic cardiovascular diseaseAsia-Pacificcardiovascular diseaseFH, familial hypercholesterolemiageneticsGWAS, genome-wide association studiesLDL, low-density lipoproteinpolygenic risk scorePRS, polygenic risk score(s)SNV, single-nucleotide variant

Identifiers

PMID36341217
PMCPMC9627888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.