Evidence map›Paper›PMID 36341186›Full record

ArticleIJU case reports2022

Progressive metastatic pheochromocytoma induced by multiple endocrine neoplasia type 2A with a lethal outcome.

Koshiro Nishimoto, Noriaki Lukas Santo, Masato Yonamine, Kazuhiro Takekoshi, Go Kaneko, Suguru Shirotake, Hisayo Fukushima, Yoshitaka Okada, Masanori Yasuda, Akihiro Sakurai and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in IJU case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Koshiro NishimotoDepartment of Uro-Oncology Saitama Medical University International Medical Center Hidaka Japan.ORCID https://orcid.org/0000-0002-3952-5643
Noriaki Lukas SantoDepartment of Uro-Oncology Saitama Medical University International Medical Center Hidaka Japan.
Masato YonamineLaboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine University of Tsukuba Tsukuba Japan.
Kazuhiro TakekoshiLaboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine University of Tsukuba Tsukuba Japan.
Go KanekoDepartment of Uro-Oncology Saitama Medical University International Medical Center Hidaka Japan.ORCID https://orcid.org/0000-0002-1796-7301
Suguru ShirotakeDepartment of Uro-Oncology Saitama Medical University International Medical Center Hidaka Japan.
Hisayo FukushimaDepartment of Cancer Genomic Medicine Saitama Medical University International Medical Center Hidaka Japan.
Yoshitaka OkadaDepartment of Diagnostic Radiology Saitama Medical University International Medical Center Hidaka Japan.
Masanori YasudaDepartment of Diagnostic Pathology the Saitama Medical University International Medical Center Hidaka Japan.
Akihiro SakuraiDepartment of Medical Genetics and Genomics Sapporo Medical University School of Medicine Sapporo Japan.
Masafumi OyamaDepartment of Uro-Oncology Saitama Medical University International Medical Center Hidaka Japan.
Kento KanaoDepartment of Uro-Oncology Saitama Medical University International Medical Center Hidaka Japan.
Saitama Medical University · JPMolina Center for Energy and the Environment · USUniversity of Tsukuba · JPSapporo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients with multiple endocrine neoplasia type 2A (MEN2A) harboring a pathological variant in the RET gene are characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. Although pheochromocytoma is currently defined as a malignant tumor, MEN2A-associated pheochromocytoma is known to have a small risk of metastasis. Case presentation: The case was a 62-year-old Japanese male with bilateral pheochromocytoma, multiple metastases in the liver and bones, and a cardiac thrombus. Genetic testing revealed a pathological variant at codon 634 of the RET gene, thereby leading a diagnosis of MTC. We considered that the multiple metastases were due to MTC; however, a liver biopsy revealed metastasis of pheochromocytoma. Conclusion: When pheochromocytoma precedes MTC, the diagnosis of MEN2A may be difficult.

Indexed as

chemotherapyembolizationMetastatic pheochromocytomamultiple endocrine neoplasia type 2thrombosis

Identifiers

PMID36341186
PMCPMC9626320
OpenAlexW4294723852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.