Evidence map›Paper›PMID 36341141›Full record

ArticleLife research2022

Hyperhomocysteinemia dysregulates plasma levels of polyunsaturated fatty acids-derived eicosanoids.

Mohamed Al-Shabrawey, Ahmed Elmarakby, Yara Samra, Mohamed Moustafa, Stephen W Looney, Krishna Rao Maddipati, Amany Tawfik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mohamed Al-ShabraweyDepartment of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
Ahmed ElmarakbyDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA.
Yara SamraDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA.
Mohamed MoustafaDepartment of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
Stephen W LooneyDepartment of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Krishna Rao MaddipatiBioactive Lipids Research Program, Department of Pathology, Wayne State University, Michigan, USA.
Amany TawfikDepartment of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
Augusta University · USSmith-Kettlewell Eye Research Institute · USMansoura University · EGOakland University · US

Funding

BMP2/ALKs Signaling System in Diabetic RetinopathyR01EY030054 · NEI · OAKLAND UNIVERSITY · PI Mohamed Al-Sayed Al-Shabrawey · 2020 to 2026
$2.0M
Homocysteine's role in Age-Related Macular DegenerationR01EY029751 · NEI · OAKLAND UNIVERSITY · PI TAWFIK, AMANY M · 2019 to 2023
$1.8M
Role of lipoxygenase pathway in early microvascular dysfunction during diabetic rR01EY023315 · NEI · AUGUSTA UNIVERSITY · PI AL-SHABRAWEY, MOHAMED AL-SAYED · 2013 to 2017
$1.8M
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
NCRR NIH HHS S10 RR027926NEI NIH HHS R01 EY023315NEI NIH HHS R01 EY029751NEI NIH HHS R01 EY030054
6 · The paper itself

Abstract

Hyperhomocysteinemia (HHcy) contributes to the incidence of many cardiovascular diseases (CVD). Our group have previously established crucial roles of eicosanoids and homocysteine in the incidence of vascular injury in diabetic retinopathy and renal injury. Using cystathionine-β-synthase heterozygous mice (cβs

Indexed as

cycloxygenasecystathionine β-synthasecytochrome-P450eicosanoidshomocysteinelipoxygenase

Identifiers

PMID36341141
PMCPMC9632953
OpenAlexW4225928389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.