ArticleFrontiers in neurology2022
Effects of variability in manually contoured spinal cord masks on fMRI co-registration and interpretation.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- CoSpine open access simultaneous cortico-spinal fMRI database of thermal pain and motor tasks.Scientific data · 2025Article
- Coupling of Low Frequency Hemodynamic Oscillations Between the Brain and Spinal Cord.Human brain mapping · 2025Article
- EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional magnetic resonance imaging of the lumbosacral cord during a lower extremity motor task.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spatial distribution of hand-grasp motor task activity in spinal cord functional magnetic resonance imaging.Human brain mapping · 2023Article
- Spatial distribution of hand-grasp motor task activity in spinal cord functional magnetic resonance imaging.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) of the human spinal cord (SC) is a unique non-invasive method for characterizing neurovascular responses to stimuli. Group-analysis of SC fMRI data involves co-registration of subject-level data to standard space, which requires manual masking of the cord and may result in bias of group-level SC fMRI results. To test this, we examined variability in SC masks drawn in fMRI data from 21 healthy participants from a completed study mapping responses to sensory stimuli of the C7 dermatome. Masks were drawn on temporal mean functional image by eight raters with varying levels of neuroimaging experience, and the rater from the original study acted as a reference. Spatial agreement between rater and reference masks was measured using the Dice Similarity Coefficient, and the influence of rater and dataset was examined using ANOVA. Each rater's masks were used to register functional data to the PAM50 template. Gray matter-white matter signal contrast of registered functional data was used to evaluate the spatial normalization accuracy across raters. Subject- and group-level analyses of activation during left- and right-sided sensory stimuli were performed for each rater's co-registered data. Agreement with the reference SC mask was associated with both rater (F
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.