Evidence map›Paper›PMID 36341032›Full record

ArticleJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2021

In vitro susceptibility of common bacterial pathogens causing respiratory tract infections in Canada to lefamulin, a new pleuromutilin.

Robert M Taylor, James A Karlowsky, Melanie R Baxter, Heather J Adam, Andrew Walkty, Philippe Lagacé-Wiens, George G Zhanel

Open access · greenAbstract read
In one paragraph

Article in Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Antimicrobial activity of lefamulin against pathogens most commonly causing community-acquired pneumonia: results from the China antimicrobial surveillance network in 2020-2022.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Robert M TaylorMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
James A KarlowskyMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Melanie R BaxterMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Heather J AdamMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Andrew WalktyMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Philippe Lagacé-WiensMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID https://orcid.org/0000-0002-5826-2869
George G ZhanelMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Manitoba Health · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Community-acquired pneumonia (CAP) is a significant global health concern. Pathogens causing CAP demonstrate increasing resistance to commonly prescribed empiric treatments. Resistance in Methods: Common bacterial causes of CAP obtained from both lower respiratory and blood specimen isolates cultured by hospital laboratories across Canada were submitted to the annual CANWARD study's coordinating laboratory in Winnipeg, Canada, from January 2015 to October 2018. A total of 876 bacterial isolates were tested against lefamulin and comparator agents using the Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution method, and minimum inhibitory concentrations (MICs) were interpreted using accepted breakpoints. Results: All

Indexed as

community-acquired pneumoniaHaemophilus influenzaelefamulinpleuromutilinStaphylococcus aureusStreptococcus pneumoniae

Identifiers

PMID36341032
PMCPMC9608697
OpenAlexW3185339026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.