ArticleFrontiers in neuroscience2022
Between-subject similarity of functional connectivity-based organization of the human periaqueductal gray related to autonomic processing.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Uncovering Hidden Patterns of Stigma Amongst Older Men With Urinary Incontinence: A Latent Profile Analysis.International journal of nursing practice · 2026Article
- Altered Periaqueductal Gray Functional Connectivity in Overactive Bladder Patients: A Resting-State Functional Magnetic Resonance Imaging Study Using Clustering Analysis.International neurourology journal · 2025Article
- Spinal Cord Lower Urinary Tract Control in Humans.Neurourology and urodynamics · 2025Article
- Quantification of Aging-Related Decreases in Sensory Innervation of the Bladder Trigone in Rats.International neurourology journal · 2024Article
- Assessment of Brainstem Functional Organization in Healthy Adults and Overactive Bladder Patients Using Ultra-High Field fMRI.Biomedicines · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The periaqueductal gray (PAG) is a brain stem area designated to play an essential role in lower urinary tract (LUT) control. Post-mortem human and animal studies have indicated that the PAG is symmetrically organized in functionally and anatomically distinct columns which are involved in sympathetic or parasympathetic autonomic control of the LUT. The current study aims to find consistency across subjects and identify homologous clusters between subjects. Here, we evaluated data from 10 female participants. During a bladder filling protocol, we ran a resting-state functional magnetic resonance imaging (fMRI) scan while participants experienced a strong desire to void. A voxel-by-voxel correlation matrix of the PAG was created and parcellated using the Louvain module detection algorithm. Resulting in a map of the PAG in which each voxel is assigned to a cluster as determined by the Louvain module detection algorithm. The spatial similarity of resulting clusters between participants was assessed by computing the Dice similarity coefficient for all cluster comparisons. Next, we designed a permutation test to create randomized parcellation maps which enabled us to statistically test the similarity values observed across participants. We observed several significantly similar clusters between subjects compared to permutations (
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