Evidence map›Paper›PMID 36340783›Full record

ArticleFrontiers in neuroscience2022

Subthreshold repetitive transcranial magnetic stimulation suppresses ketamine-induced poly population spikes in rat sensorimotor cortex.

Wenxuan Jiang, Robert Isenhart, Robert Sutherland, Zhouxiao Lu, Huijing Xu, John Pace, Michael A Bonaguidi, Darrin J Lee, Charles Y Liu, Dong Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wenxuan JiangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Robert IsenhartRancho Los Amigos National Rehabilitation Center, Downey, CA, United States.
Robert SutherlandDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Zhouxiao LuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Huijing XuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
John PaceDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Michael A BonaguidiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Darrin J LeeDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Charles Y LiuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Dong SongDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
University of Southern California · USRancho Los Amigos National Rehabilitation Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cortical oscillations within or across brain regions play fundamental roles in sensory, motor, and memory functions. It can be altered by neuromodulations such as repetitive transcranial magnetic stimulation (rTMS) and pharmacological manipulations such as ketamine. However, the neurobiological basis of the effects of rTMS and ketamine, as well as their interactions, on cortical oscillations is not understood. In this study, we developed and applied a rodent model that enabled simultaneous rTMS treatment, pharmacological manipulations, and invasive electrophysiological recordings, which is difficult in humans. Specifically, a miniaturized C-shaped coil was designed and fabricated to deliver focal subthreshold rTMS above the primary somatosensory (S1) and motor (M1) cortex in rats. Multi-electrode arrays (MEA) were implanted to record local field potentials (LFPs) and single unit activities. A novel form of synchronized activities, poly population spikes (PPS), was discovered as the biomarker of ketamine in LFPs. Brief subthreshold rTMS effectively and reversibly suppressed PPS while increasing the firing rates of single unit activities. These results suggest that ketamine and rTMS have convergent but opposing effects on cortical oscillations and circuits. This highly robust phenomenon has important implications to understanding the neurobiological mechanisms of rTMS and ketamine as well as developing new therapeutic strategies involving both neuromodulation and pharmacological agents.

Indexed as

ketaminelocal field potentialsneuromodulationpopulation spikesrTMSspikes

Identifiers

PMID36340783
PMCPMC9633989
OpenAlexW4306966023

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.