ArticleFrontiers in neuroscience2022
The outcome of severely injured patients following traumatic brain injury is affected by gender-A retrospective, multicenter, matched-pair analysis utilizing data of the TraumaRegister DGU
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Association Between Sex and Mortality After Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neurocritical care · 2026Pooled it
- Sex and gender bias in major trauma care: a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Oestradiol dynamics after polytrauma are linked to injury severity and adverse outcomes.Frontiers in endocrinology · 2026Article
- Sex-Specific Differences in Sepsis Development in Polytrauma Patients Undergoing Stand-Alone Definitive Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Differences in Eotaxin Serum Levels between Polytraumatized Patients with and without Concomitant Traumatic Brain Injury-A Matched Pair Analysis.Journal of clinical medicine · 2024Article
- Cognitive impairment in Chinese traumatic brain injury patients: from challenge to future perspectives.Frontiers in neuroscience · 2024Review
- Antioxidant theranostic copolymer-mediated reduction in oxidative stress following traumatic brain injury improves outcome in a mouse model.Advanced therapeutics · 2023Article
- Identifying predictive factors for mortality in patients with TBI at a neurosurgery department.Journal of medicine and life · 2023Observational
- Therapy of traumatic brain injury by modern agents and traditional Chinese medicine.Chinese medicine · 2023Review
- Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Sex-related differences in extracranial complications in patients with traumatic brain injury.Frontiers in neurology · 2023Article
- Social Determinants of Health and Their Role in Basilar Skull Fracture Outcomes: A Level 1 Trauma Multicenter Retrospective Study.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Traumatic brain injury (TBI) causes a major health-concern globally. Gender-dependent differences in mortality outcome after TBI have been controversially discussed. Materials and methods: We conducted a retrospective, multicenter, matched-pair analysis using data collected by the TraumaRegister DGU Results: Average age at injury was 67.5 ± 19.6 years in women and 66.7 ± 19.1 years in men. Mean Injury Severity Score (ISS) was 21.3 ± 8.1 in women and 21.6 ± 8.2 in men. While women were more likely to die within the first week after trauma, the mortality was significantly higher in men overall (30.8 vs. 29.2%, Discussion: Gender-specific differences in the clinical outcome of severely injured patients with leading TBI could be detected. While women are overall characterized by an advantage in survival, this feature is not equally reproducible in premenopausal women. Therefore, the exact pathophysiological reasons for the described survival advantages of women will have to be explored in further prospective clinical studies.
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