Evidence map›Paper›PMID 36340644›Full record

ArticleBrain multiphysics2022

Anisotropic mechanical properties in the healthy human brain estimated with multi-excitation transversely isotropic MR elastography.

Daniel R Smith, Diego A Caban-Rivera, Matthew D J McGarry, L Tyler Williams, Grace McIlvain, Ruth J Okamoto, Elijah E W Van Houten, Philip V Bayly, Keith D Paulsen, Curtis L Johnson

Open access · goldAbstract read
In one paragraph

Article in Brain multiphysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  6. Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026
    Article
  7. Article
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  10. 3D rotational shear wave elasticity imaging (3D-RSWEI) in anisotropic lattice phantoms.Journal of the mechanical behavior of biomedical materials · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Daniel R SmithDepartment of Biomedical Engineering, University of Delaware, Newark DE 19711.
Diego A Caban-RiveraDepartment of Biomedical Engineering, University of Delaware, Newark DE 19711.
Matthew D J McGarryThayer School of Engineering, Dartmouth College, Hanover NH 03755.
L Tyler WilliamsDepartment of Biomedical Engineering, University of Delaware, Newark DE 19711.
Grace McIlvainDepartment of Biomedical Engineering, University of Delaware, Newark DE 19711.
Ruth J OkamotoDepartment of Mechanical Engineering & Materials Science, Washington University in St. Louis, St. Louis MO 63130.
Elijah E W Van HoutenDépartement de génie mécanique, Université de Sherbrooke, Sherbrooke, QC, Canada J1K 2R1.
Philip V BaylyDepartment of Mechanical Engineering & Materials Science, Washington University in St. Louis, St. Louis MO 63130.
Keith D PaulsenThayer School of Engineering, Dartmouth College, Hanover NH 03755.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark DE 19711.
University of Delaware · USDartmouth College · USWashington University in St. Louis · USUniversité de Sherbrooke · CA

Funding

High-Resolution, Anisotropic MR Elastography of the BrainR01EB027577 · NIBIB · UNIVERSITY OF DELAWARE · PI BAYLY, PHILIP V, JOHNSON, CURTIS L · 2019 to 2022
$2.7M
Mechanical integrity of memory systems in mild cognitive impairmentR01AG058853 · NIA · UNIVERSITY OF DELAWARE · PI JOHNSON, CURTIS L · 2018 to 2022
$2.3M
NIA NIH HHS R01 AG058853NIBIB NIH HHS R01 EB027577
6 · The paper itself

Abstract

Magnetic resonance elastography (MRE) is an MRI technique for imaging the mechanical properties of brain in vivo, and has shown differences in properties between neuroanatomical regions and sensitivity to aging, neurological disorders, and normal brain function. Past MRE studies investigating these properties have typically assumed the brain is mechanically isotropic, though the aligned fibers of white matter suggest an anisotropic material model should be considered for more accurate parameter estimation. Here we used a transversely isotropic, nonlinear inversion algorithm (TI-NLI) and multiexcitation MRE to estimate the anisotropic material parameters of individual white matter tracts in healthy young adults. We found significant differences between individual tracts for three recovered anisotropic parameters: substrate shear stiffness,

Indexed as

AnisotropyBrainMagnetic Resonance ElastographyStiffnessWhite Matter

Identifiers

PMID36340644
PMCPMC9635552
OpenAlexW4285221261

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.