Evidence map›Paper›PMID 36340495›Full record

ArticleHeart rhythm O22022

Machine learning for multidimensional response and survival after cardiac resynchronization therapy using features from cardiac magnetic resonance.

Derek J Bivona, Srikar Tallavajhala, Mohamad Abdi, Pim J A Oomen, Xu Gao, Rohit Malhotra, Andrew E Darby, Oliver J Monfredi, J Michael Mangrum, Pamela K Mason and 6 more

Abstract read
In one paragraph

Article in Heart rhythm O2, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. The saga of dyssynchrony imaging: Are we getting to the point.Frontiers in cardiovascular medicine · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Derek J BivonaDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Srikar TallavajhalaDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Mohamad AbdiDepartment of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia.
Pim J A OomenDepartment of Biomedical Engineering, University of California, Irvine, California.
Xu GaoDepartment of Medicine, Northwestern University, Chicago, Illinois.
Rohit MalhotraDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Andrew E DarbyDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Oliver J MonfrediDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
J Michael MangrumDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Pamela K MasonDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Sula MazimbaDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Michael SalernoDepartments of Medicine and Radiology, Stanford University, Palo Alto, California.
Christopher M KramerDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Frederick H EpsteinDepartment of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia.
Jeffrey W HolmesDepartments of Medicine, Surgery, and Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama.
Kenneth C BilchickDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia.

Funding

Multiscale Models for Predicting Short and Long-term Outcome of Cardiac Resynchronization TherapyR01HL159945 · NHLBI · UNIVERSITY OF VIRGINIA · PI BILCHICK, KENNETH C, HOLMES, JEFFREY W · 2021 to 2024
$2.6M
NHLBI NIH HHS R01 HL159945
6 · The paper itself

Abstract

Background: Cardiac resynchronization therapy (CRT) response is complex, and better approaches are required to predict survival and need for advanced therapies. Objective: The objective was to use machine learning to characterize multidimensional CRT response and its relationship with long-term survival. Methods: Associations of 39 baseline features (including cardiac magnetic resonance [CMR] findings and clinical parameters such as glomerular filtration rate [GFR]) with a multidimensional CRT response vector (consisting of post-CRT left ventricular end-systolic volume index [LVESVI] fractional change, post-CRT B-type natriuretic peptide, and change in peak VO Results: Among 200 patients (median age 67.4 years, 27.0% women) with CRT and CMR, associations with more than 1 response parameter were noted for the CMR CURE-SVD dyssynchrony parameter (associated with post-CRT brain natriuretic peptide [BNP] and LVESVI fractional change) and GFR (associated with peak VO Conclusion: Machine learning characterizes distinct CRT response clusters influenced by CMR features, kidney function, and other factors. These clusters have a strong and additive influence on long-term survival relative to baseline features.

Indexed as

Cardiac resynchronization therapyHeart failureImplantable cardioverter-defibrillatorMachine learningMagnetic resonance imaging

Identifiers

PMID36340495
PMCPMC9626744

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.