Evidence map›Paper›PMID 36340455›Full record

ReviewCancer diagnosis & prognosis

Epigenetic Mechanisms in Breast Adenocarcinoma: Novel DNA Methylation Patterns.

Georgios I Metaxas, Evangelos Tsiambas, Spyridon Marinopoulos, Despoina Spyropoulou, Loukas Manaios, Maria Adamopoulou, Evangelos Falidas, Dimitrios Peschos, Helen Kalkani, Constantine Dimitrakakis

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Georgios I MetaxasBreast Unit, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Evangelos TsiambasDepartment of Cytology, 417 VA (NIMTS) Hospital, Athens, Greece.
Spyridon MarinopoulosBreast Unit, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Despoina SpyropoulouDepartment of Radiation Oncology, Medical School, University of Patras, Patras, Greece.
Loukas ManaiosDepartment of Surgery, Bioclinic Medical Center, Athens, Greece.
Maria AdamopoulouLaboratory of Molecular Microbiology and Immunology, Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, Athens, Greece.
Evangelos FalidasDepartment of Surgery, Halkida General Hospital, Halkida, Greece.
Dimitrios PeschosDepartment of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Helen KalkaniLeucippus Technology Park, NCSR Demokritos, Athens, Greece.
Constantine DimitrakakisBreast Unit, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
General Hospital of Attica · GRNIMTS Hospital · GRUniversity of Ioannina · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast adenocarcinoma is a leading cause of death in females worldwide. A broad spectrum of genetic and epigenetic alterations has been already identified and reported in millions of examined cancerous substrates, evidence of a high-level genomic heterogeneity that characterizes these malignancies. Concerning epigenetic changes and imbalances that critically affect progression and prognosis in the corresponding patients, DNA methylation, histone modifications (acetylation), micro-RNAs (miRs) alterations and chromatin re-organization represent the main mechanisms. Referring to DNA methylation, promoter hyper-hypo methylation in critical tumour suppressor and oncogenes is implicated in normal epithelia transformation to their neoplastic and finally malignant cyto-phenotypes. The current review is focused on the different methylation patterns and mechanisms detected in breast adenocarcinoma and their impact on the corresponding groups of patient response to specific chemotherapeutic regimens and life span prognosis.

Indexed as

adenocarcinomaBreastDNAepigeneticsgenesmethylationreview

Identifiers

PMID36340455
PMCPMC9628153
OpenAlexW4308553335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.