Evidence map›Paper›PMID 36340440›Full record

ArticleJournal of translational science2022

Bell's palsy and lip HSV-1 infection: importance of subcutaneous access.

Marina S Boukhvalova, Emma Mortensen, Diego Lopez, Betsy C Herold, Jorge Cg Blanco

Open access · diamondAbstract read
In one paragraph

Article in Journal of translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marina S BoukhvalovaSigmovir Biosystems, Inc., Rockville, MD, USA.
Emma MortensenSigmovir Biosystems, Inc., Rockville, MD, USA.
Diego LopezSigmovir Biosystems, Inc., Rockville, MD, USA.
Betsy C HeroldAlbert Einstein College of Medicine, Bronx, NY, USA.
Jorge Cg BlancoSigmovir Biosystems, Inc., Rockville, MD, USA.
Sigmovir Biosystems (United States) · USAlbert Einstein College of Medicine · US

Funding

Cotton Rat: Animal Model Predictive of Clinical Responses to HSV VaccinesR41AI091246 · NIAID · VIRION SYSTEMS, INC. · PI BOUKHVALOVA, MARINA S · 2010 to 2011
$543k
NIAID NIH HHS R41 AI091246
6 · The paper itself

Abstract

Although HSV-1 has been implicated in facial palsy for a long time, testing and treating for HSV is not routine. The lack of a meaningful demonstration of how HSV-1 would cause facial palsy has limited progress in this field. Herein we demonstrate that the depth of the lip HSV-1 infection defines the course of the disease, with deeper subcutaneous infection allowing virus access to the facial nerve and causing facial palsy. HSV-1 inoculated subcutaneously caused extensive facial paralysis in cotton rats

Indexed as

bell’s palsycotton ratdemyelinationfacial paralysisHSV-1subcutaneous

Identifiers

PMID36340440
PMCPMC9631455
OpenAlexW4308551576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.