Evidence map›Paper›PMID 36340159›Full record

ArticleACS omega2022

Development of Red-Emissive Porphyrin Graphene Quantum Dots (PGQDs) for Biological Cell-Labeling Applications.

Sarah Reagen, Yingfen Wu, Rahul Shahni, Wen Sun, Jin Zhang, Qianli R Chu, Xiaodong Hou, Colin Combs, Julia Xiaojun Zhao

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sarah ReagenDepartment of Chemistry, University of North Dakota, Grand Forks, North Dakota58202, United States.ORCID https://orcid.org/0000-0003-2873-0040
Yingfen WuDepartment of Chemistry, University of North Dakota, Grand Forks, North Dakota58202, United States.
Rahul ShahniDepartment of Chemistry, University of North Dakota, Grand Forks, North Dakota58202, United States.
Wen SunDepartment of Chemistry, University of North Dakota, Grand Forks, North Dakota58202, United States.ORCID https://orcid.org/0000-0002-4172-5177
Jin ZhangInstitute for Energy Studies, University of North Dakota, Grand Forks, North Dakota58202, United States.
Qianli R ChuDepartment of Chemistry, University of North Dakota, Grand Forks, North Dakota58202, United States.
Xiaodong HouInstitute for Energy Studies, University of North Dakota, Grand Forks, North Dakota58202, United States.ORCID https://orcid.org/0000-0001-7794-979X
Colin CombsDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, North Dakota58202, United States.
Julia Xiaojun ZhaoDepartment of Chemistry, University of North Dakota, Grand Forks, North Dakota58202, United States.ORCID https://orcid.org/0000-0002-9603-666X
University of North Dakota · US

Funding

Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
NIGMS NIH HHS P20 GM113123
6 · The paper itself

Abstract

Red and near-infrared emission is a highly desirable feature for fluorescent nanoparticles in biological applications mainly due to longer wavelengths more easily being able to deeply penetrate tissues, organs, skin, and other organic components, while less autofluorescence interference would be produced. Additionally, graphene quantum dots (GQDs) that contain unique optical and electrical features have been targeted for their use in cell labeling applications as well as environmental analysis. Their most desirable features come in the form of low toxicity and biocompatibility; however, GQDs are frequently reported to have blue or green emission light and not the more advantageous red/NIR emission light. Furthermore, porphyrins are a subgroup of heterocyclic macrocycle organic compounds that are also naturally occurring pigments in nature that already contain the desired red-emission fluorescence. Therefore, porphyrins have been used previously to synthesize nanomaterials and for nanoparticle doping in order to incorporate the red/NIR emission light property into particles that otherwise do not contain the desired emission light. Meso-tetra(4-carboxyphenyl)porphine (TCPP) is one type of porphyrin with a large conjugated π-electron system and four carboxyl groups on its exterior benzene rings. These two key characteristics of TCPP make it ideal for incorporation into GQDs, as it would design and synthesize red-emissive material as well as give rise to excellent water solubility. In this work, TCPP is used in tangent with

Identifiers

PMID36340159
PMCPMC9631800
OpenAlexW4306840218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.