Evidence map›Paper›PMID 36339946›Full record

ArticleFrontiers in ecology and evolution2022

Natural and Engineered Sex Ratio Distortion in Insects.

Austin Compton, Zhijian Tu

Abstract read
In one paragraph

Article in Frontiers in ecology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Mosquito sex determination: recent advances and applications.Current opinion in insect science · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Austin ComptonDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.
Zhijian TuDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.

Funding

Sex ratio distortion in Aedes aegyptiR01AI157491 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2020 to 2024
$3.1M
Mechanism and application of male determination in aedine mosquitoesR01AI123338 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2016 to 2020
$2.9M
Guy1-conferred female lethality: mechanism and application for mosquito controlR01AI121284 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2016 to 2020
$2.0M
The male-determining locus of Culex quinquefasciatusR21AI154871 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2020 to 2021
$438k
NIAID NIH HHS R01 AI121284NIAID NIH HHS R01 AI123338NIAID NIH HHS R01 AI157491NIAID NIH HHS R21 AI154871
6 · The paper itself

Abstract

Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can result in sex ratio distortion (SRD). Recent advances in sex chromosome genomics and CRISPR/Cas9-mediated genome editing brought significant insights into the molecular regulators of sex determination in an increasing number of insects and provided new ways to engineer SRD. We review these advances and discuss both naturally occurring and engineered SRD in the context of the Anthropocene. We emphasize SRD-mediated biological control of insects to help improve One Health, sustain agriculture, and conserve endangered species.

Identifiers

PMID36339946
PMCPMC9635402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.