Evidence map›Paper›PMID 36339924›Full record

ArticleClinical pathology (Thousand Oaks, Ventura County, Calif.)

Lymph Nodes With Germinal Centers Are Not Associated With Tumor Response After Neoadjuvant Treatment in Locally Advanced Rectal Cancer.

Ihsane El Otmani, Boubacar Effared, Fatima El Agy, Mohammed El Abkari, Khalid Mazaz, El Bachir Benjelloun, Abdelmalek Ousadden, Zineb Benbrahim, Touria Bouhafa, Laila Chbani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pathology (Thousand Oaks, Ventura County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ihsane El OtmaniLaboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Boubacar EffaredLaboratory of Anatomic Pathology and Molecular Pathology, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Fatima El AgyLaboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Mohammed El AbkariDepartment of Gastroenterology, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Khalid MazazDepartment of General surgery, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
El Bachir BenjellounDepartment of General surgery, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Abdelmalek OusaddenDepartment of General surgery, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Zineb BenbrahimDepartment of Medical Oncology, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Touria BouhafaDepartment of Radiotherapy, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Laila ChbaniLaboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed BenAbdellah, Fez, Morocco.
Sidi Mohamed Ben Abdellah University · MAUniversité Hassan 1er · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with locally advanced rectal cancer, neoadjuvant radiotherapy or chemoradiotherapy followed by total mesorectal excision as a standard of care. We aimed to explore the number, size, germinal centers, extracapsular invasion of lymph nodes (LN), and their impact on overall survival and disease free survival. Furthermore we also investigated the characteristics of lymph nodes in patients who received neoadjuvant therapy and those who underwent surgery between 2011 and 2018. The count and measurement of lymph nodes was assessed by careful visual inspection and manual palpation. The predictive cut-off value of the lymph node ratio (LNR) was determined based on the receiver operating characteristic (ROC), method and the survival outcomes based on Kaplan-Meier curves. We found that the size and the number of lymph nodes decreased significantly after neoadjuvant treatment. The mean LN for patients who received neoadjuvant therapy was 12.68 ± 6.69 and for patients who did not receive neoadjuvant therapy was 16.29 ± 5.61 (

Indexed as

germinal centerslymph node characteristicsMorocconeoadjuvant treatmentRectal cancer

Identifiers

PMID36339924
PMCPMC9629553
OpenAlexW4308551570

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.