Evidence map›Paper›PMID 36339612›Full record

ArticleFrontiers in pharmacology2022

LTT and HLA testing as diagnostic tools in Spanish vancomycin-induced DRESS cases: A case-control study.

Teresa Bellón, Victoria Lerma, Javier Guijarro, Elena Ramírez, Celia Martínez, Carmelo Escudero, Ana M Fiandor, Ruth Barranco, Manuel de Barrio, Francisco de Abajo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Tools for Etiologic Diagnosis of Drug-Induced Allergic Conditions.International journal of molecular sciences · 2023
    Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Teresa BellónDrug Hypersensitivity Laboratory, Institute for Health Research Hospital Universitario La Paz (IdiPaz), Madrid, Spain.
Victoria LermaClinical Pharmacology Unit, Hospital Universitario Príncipe de Asturias, Madrid, Spain.
Javier GuijarroClinical Pharmacology Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, IdiPAZ, School of Medicine, Autonomous University of Madrid, Madrid, Spain.
Elena RamírezClinical Pharmacology Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, IdiPAZ, School of Medicine, Autonomous University of Madrid, Madrid, Spain.
Celia MartínezDrug Hypersensitivity Laboratory, Institute for Health Research Hospital Universitario La Paz (IdiPaz), Madrid, Spain.
Carmelo EscuderoAllergy Department, Hospital Universitario Niño Jesús, Madrid, Spain.
Ana M FiandorAllergy Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, Madrid, Spain.
Ruth BarrancoAllergy Department, Hospital Universitario Doce de Octubre, Madrid, Spain.
Manuel de BarrioAllergy Department, Hospital Gregorio Marañón, Madrid, Spain.
Francisco de AbajoClinical Pharmacology Unit, Hospital Universitario Príncipe de Asturias, Madrid, Spain.
Rosario CabañasAllergy Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, Madrid, Spain.
PIELenRed Study Group
Hospital Universitario La Paz · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESHospital General Universitario Gregorio Marañón · ESHospital Infantil Universitario Niño Jesús · ESHospital La Paz Institute for Health Research · ESHospital Universitario 12 De Octubre · ESUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T-cell-mediated off-target adverse reaction. DRESS cases caused by vancomycin have often been reported. The HLA-A*32:01 allele has been associated with genetic susceptibility to vancomycin-induced DRESS in US citizens of European descent. We have analyzed the association of the HLA-A*32:01 allele in 14 Spanish DRESS cases in which vancomycin was suspected as the culprit drug, and the lymphocyte transformation test (LTT) as an

Indexed as

DRESSdrug causality algorithmdrug hypersensitivityHLALTTsevere cutaneous adverse reactionsvancomycin

Identifiers

PMID36339612
PMCPMC9631441
OpenAlexW4306867195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.