ArticleiScience2022
bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- LL3, a homolog of LONESOME HIGHWAY, regulates vascular cell proliferation in the root apical meristem.Plant & cell physiology · 2026Article
- TMO5 regulates PIN1 polarity convergence and organogenesis downstream of MONOPTEROS in the Arabidopsis shoot.Development (Cambridge, England) · 2025Article
- An AINTEGUMENTA phosphoswitch controls bilateral stem cell activity during secondary growth.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- SPL13 controls a root apical meristem phase change by triggering oriented cell divisions.Science (New York, N.Y.) · 2024Article
- Molecular Characterization, Expression Pattern, DNA Methylation and Gene Disruption ofAnimals : an open access journal from MDPI · 2024Article
- Hormonal control of the molecular networks guiding vascular tissue development in the primary root meristem of Arabidopsis.Journal of experimental botany · 2023Review
- Cytokinins - regulators ofFrontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root, shoot, and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic helix-loop-helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.