ArticleFrontiers in public health2022
Lead exposure is non-linearly associated with subclinical myocardial injury in the general population without cardiovascular disease.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Global burden of cardiovascular disease attributable to lead exposure: based on the global burden of disease study 2021.Frontiers in public health · 2026Article
- Exposomic Determinants of Atherosclerosis: Recent Evidence.Current atherosclerosis reports · 2025Review
- Global, regional, and national burden of ischemic heart disease attributable to lead exposure, 1990-2021: decomposition, frontier, and projection analysis.Frontiers in public health · 2025Article
- Impact of lead exposure on global chronic kidney disease attributable to hypertension: deaths and disability-adjusted life years from 1990 to 2021 and projected trends for 2022-2036.Frontiers in public health · 2025Article
- Environmental Pollution and Cardiovascular Disease: Part 1 of 2: Air Pollution.JACC. Advances · 2024Review
- The Contribution of Declines in Blood Lead Levels to Reductions in Blood Pressure Levels: Longitudinal Evidence in the Strong Heart Family Study.Journal of the American Heart Association · 2024Article
- Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Growing studies have focused on the effect of lead exposure on human circulatory system, while the relationship between lead exposure and subclinical myocardial injury (SC-MI) is still poorly known. Therefore, this study was to explore the effect of lead exposure on SC-MI. Methods: The study included 6,272 individuals aged 40 and older without cardiovascular disease (CVD) from the third National Health and Nutrition Examination Survey. Blood lead was used as an alternative marker of lead exposure. Multivariable logistic regression models, restricted cubic spline and threshold effect analyses were performed to investigate the effect of blood lead on SC-MI. Results: After adjusting for age, sex, race, diabetes, hypertension, systolic blood pressure, body mass index, waist-to-hip ratio, triglycerides, total cholesterol, creatinine, fasting plasma glucose and hemoglobin Alc, higher blood lead level was independently related to higher risk of SC-MI (OR 1.047, 95% CI [1.018, 1.077]; Conclusions: Blood lead was non-linearly related to SC-MI in population free from CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.