Evidence map›Paper›PMID 36339088›Full record

ArticleTemperature (Austin, Tex.)2022

CORM-401, an orally active carbon monoxide-releasing molecule, increases body temperature by activating non-shivering thermogenesis in rats.

Mateus R Amorim, Roberta Foresti, Djamal Eddine Benrahla, Roberto Motterlini, Luiz G S Branco

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Temperature (Austin, Tex.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Mateus R AmorimDental School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Roberta ForestiFaculty of Health, University Paris Est Créteil, INSERM, IMRB, Créteil, France.ORCID https://orcid.org/0000-0002-0836-7937
Djamal Eddine BenrahlaFaculty of Health, University Paris Est Créteil, INSERM, IMRB, Créteil, France.
Roberto MotterliniFaculty of Health, University Paris Est Créteil, INSERM, IMRB, Créteil, France.ORCID https://orcid.org/0000-0003-2684-2612
Luiz G S BrancoDental School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Inserm · FRJohns Hopkins University · USUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thermoregulation is critical in health and disease and is tightly controlled to maintain body temperature homeostasis. Carbon monoxide (CO), an endogenous gasotransmitter produced during heme degradation by heme oxygenases, has been suggested to play a role in body core temperature (Tb) regulation. However, a direct involvement of CO in thermoregulation has not been confirmed and its mechanism(s) of action remain largely unknown. In the present study we characterized the effects of systemic delivery of CO by administration of an orally active CO-releasing molecule (CORM-401) on Tb regulation in conscious freely moving rats. Specifically, we evaluated the main thermo effectors in rats treated with CORM-401 by assessing: (i) non-shivering thermogenesis,

Indexed as

brown adipose tissueCarbon monoxideheme oxygenasemetabolismthermoregulation

Identifiers

PMID36339088
PMCPMC9629103
OpenAlexW4224993688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.