ArticleFrontiers in genetics2022
An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy.
Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- What Is-and What Is Not-Immunogenic Cell Death? Functional Definitions, Experimental Standards, and Common Pitfalls.International journal of molecular sciences · 2026Review
- Antitumoral and Immunogenic Capacity of β-D-Glucose-Reduced Silver Nanoparticles in Breast Cancer.International journal of molecular sciences · 2023Article
- Immune cell death-related lncRNA signature as a predictive factor of clinical outcomes and immune checkpoints in gastric cancer.Frontiers in pharmacology · 2023Article
- Trial watch: chemotherapy-induced immunogenic cell death in oncology.Oncoimmunology · 2023Review
- PTPRC promoted CD8+ T cell mediated tumor immunity and drug sensitivity in breast cancer: based on pan-cancer analysis and artificial intelligence modeling of immunogenic cell death-based drug sensitivity stratification.Frontiers in immunology · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
As a type of regulated cell death (RCD), immunogenic cell death (ICD) can initiate the adaptive immune responses. Numerous reports highlight the capacity of ICD to alter the tumor immune microenvironment by releasing Damage-Associated Molecular Patterns (DAMP) or danger signals to boost the efficacy of immunotherapy. Therefore, identification of the ICD-associated biomarkers is crucial for the prediction of ICD-induced immune responses. In this report, the consensus clustering technique was used to identify two subcategories (subtypes) linked to ICD. In comparison to the ICD-low subcategory, the ICD-high subcategory showed longer survival and more immune cell infiltration. Then, a novel ICD-associated prognostic model was developed and validated for predicting the survival of patients with breast invasive carcinomas (BRCA) and is linked to the tumor immune microenvironment. To conclude, a novel ICD-based BRCA classification scheme was designed. For individuals with BRCA, this categorization will be crucial for directing the assessment of prognosis and treatment.
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