Evidence map›Paper›PMID 36338933›Full record

ArticleOsteoarthritis and cartilage open2022

Expedited gene delivery for osteochondral defect repair in a rabbit knee model: A one-year investigation.

Christopher V Nagelli, Rodolfo E De La Vega, Michael Coenen, Consuelo Lopez De Padilla, Joseph A Panos, Alejandro Tovar, Sebastian A Müller, Christopher H Evans

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Gene Delivery to Chondrocytes.Advances in experimental medicine and biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

Christopher V NagelliMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Rodolfo E De La VegaMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Michael CoenenMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Consuelo Lopez De PadillaMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Joseph A PanosMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Alejandro TovarMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Sebastian A MüllerMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Christopher H EvansMusculoskeletal Gene Therapy Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic · US

Funding

Musculoskeletal Research Training ProgramT32AR056950 · NIAMS · MAYO CLINIC ROCHESTER · PI Jennifer J Westendorf · 2009 to 2026
$7.0M
NIAMS NIH HHS T32 AR056950
6 · The paper itself

Abstract

Objective: To evaluate a single-step, gene-based procedure for repairing osteochondral lesions. Design: Osteochondral lesions were created in the patellar groove of skeletally mature rabbits. Autologous bone marrow aspirates were mixed with adenovirus vectors carrying cDNA encoding green fluorescent protein (Ad.GFP) or transforming growth factor-β Results: At 2 weeks, GFP expression was seen at variable levels within the cartilaginous lesion. At 3 months, there was no statistically significant improvement (p > 0.05) in healing of lesions receiving Ad.TGF-β Conclusions: This approach to improving the repair of osteochondral lesions needs further refinement to reduce variability and provide a more robust outcome.

Indexed as

Cartilage repairGene deliveryKneeLong-termOsteochondral defectsRabbit

Identifiers

PMID36338933
PMCPMC9635382
OpenAlexW4220721716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.