ReviewFrontiers in behavioral neuroscience2022
Early life exposure to unpredictable parental sensory signals shapes cognitive development across three species.
Review in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Loss of pleasure (Anhedonia): A sex-dependent, cross-species consequence of unpredictable signals to the perinatal brain.Neurobiology of stress · 2026Article
- Early-life adversity in rodents: Experimental design is of the essence.Neurobiology of stress · 2026Article
- Unpredictable maternal signals and developmental profiles of child executive function from infancy to early childhood.Developmental cognitive neuroscience · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Unpredictability is a childhood adversity that contributes to mental health problems.Nature. Mental health · 2026Article
- Prenatal maternal mood instability and child externalizing problems: An ecological momentary assessment study.Journal of affective disorders · 2025Article
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Emotional Brain Development: Neurobiological Indicators from Fetus Through Toddlerhood.Brain sciences · 2025Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Contribution of an under-recognized adversity to child health risk: large-scale, population-based ACEs screening.medRxiv : the preprint server for health sciences · 2025Article
- Mothering matters: Towards a better understanding of disrupted infant-caregiver relationships in both mother and offspring.Neurobiology of stress · 2025Review
- Measuring neuroplasticity in human development: the potential to inform the type and timing of mental health interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms.Neurobiology of stress · 2024Review
- Leveraging the science of early life predictability to inform policies promoting child health.Developmental cognitive neuroscience · 2024Review
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.bioRxiv : the preprint server for biology · 2024Article
- Microglia: The Drunken Gardeners of Early Adversity.Biomolecules · 2024Review
- The causal structure and computational value of narratives.Trends in cognitive sciences · 2024Review
- Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome.Neurobiology of stress · 2024Article
- Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment.Journal of mood and anxiety disorders · 2024Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Exposure to early life adversity has long term consequences on cognitive function. Most research has focused on understanding components of early life adversities that contribute to later risk, including poverty, trauma, maltreatment, and neglect. Whereas these factors, in the aggregate, explain a significant proportion of emotional and cognitive problems, there are serious gaps in our ability to identify potential mechanisms by which early life adversities might promote vulnerability or resilience. Here we discuss early life exposure to unpredictable signals from the caretaker as an understudied type of adversity that is amenable to prevention and intervention. We employ a translational approach to discover underlying neurobiological mechanisms by which early life exposure to unpredictable signals sculpts the developing brain. First, we review evidence that exposure to unpredictable signals from the parent during sensitive periods impacts development of neural circuits. Second, we describe a method for characterizing early life patterns of sensory signals across species. Third, we present published and original data illustrating that patterns of maternal care predict memory function in humans, non-human primates, and rodents. Finally, implications are discussed for identifying individuals at risk so that early preventive-intervention can be provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.