Evidence map›Paper›PMID 36338830›Full record

ArticleLeukemia research reports2022

The treatment of acute lymphoblastic leukemia in Jehovah's Witnesses and patients who cannot accept blood products.

Nina Nguyen, Ellen Madarang, Alvaro Alencar, Justin Watts, Terrence Bradley

Open access · goldAbstract readCase Reports
In one paragraph

Article in Leukemia research reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nina NguyenUniversity of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center,United States.
Ellen MadarangUniversity of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center,United States.
Alvaro AlencarLymphoma Program, Division of Hematology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center,United States.
Justin WattsLeukemia Program, Division of Hematology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center,United States.
Terrence BradleyLeukemia Program, Division of Hematology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center,United States.
Sylvester Comprehensive Cancer Center · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Jehovah's Witnesses cannot accept blood products based upon religious beliefs, and when they present with acute leukemia, the ideal treatment strategy can be controversial. We present six cases of Jehovah's Witnesses with acute lymphoblastic leukemia and show that complete remission can be achieved without using anthracycline in 83% (5/6) of patients. We also report, for the first time in this population, that the use of agents with novel mechanisms of action, such as blinatumomab and nelarabine, is associated with minimal myelosuppression and can produce durable responses, with 2 of 6 patients still alive in CR3 at 4.9 and 6.6 years.

Indexed as

BlinatumomabChemotherapyJehovah's WitnessLeukemiaNelarabine

Identifiers

PMID36338830
PMCPMC9630781
OpenAlexW4307392374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.