Evidence map›Paper›PMID 36338478›Full record

ArticleFrontiers in physiology2022

Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells

Alyssa R Goldberg, Megan Ferguson, Sarit Pal, Rachel Cohen, David J Orlicky, Rebecca L McCullough, Joseph M Rutkowski, Matthew A Burchill, Beth A Jirón Tamburini

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Lymphatic vasculature in ovarian cancer.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alyssa R GoldbergDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology & Nutrition. Children's Hospital Colorado, Digestive Health Institute- Pediatric Liver Center, University of Colorado School of Medicine, Aurora, CO, United States.
Megan FergusonDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, United States.
Sarit PalDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, United States.
Rachel CohenDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, United States.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Rebecca L McCulloughDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado School of Medicine, Aurora, CO, United States.
Joseph M RutkowskiDivision of Lymphatic Biology, Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX, United States.
Matthew A BurchillDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, United States.
Beth A Jirón TamburiniDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, United States.
University of Colorado Denver · USBryan College · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Montana · US

Funding

Cooperation between lymphatic stroma and hematopoietic cells shapes protective immunityR01AI121209 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Beth Ann Tamburini · 2016 to 2026
$4.5M
PD-L1 reverse signaling in dermal DCs promotes DC migration and skin immunity to cutaneous pathogensR01AI155474 · NIAID · UNIVERSITY OF COLORADO DENVER · PI TAMBURINI, BETH ANN · 2020 to 2024
$2.3M
Oxidized LDL dependent reprogramming of the liver lymphatic endotheliumR01DK125595 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURCHILL, MATTHEW A · 2020 to 2023
$1.7M
Inflammaging and ADRD: Investigating the Role of Complement and Alcohol.R00AA025386 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI SMATHERS MCCULLOUGH, REBECCA LEANNE · 2018 to 2020
$993k
Molecular tracking of antigen following vaccinationR21AI155929 · NIAID · UNIVERSITY OF COLORADO DENVER · PI TAMBURINI, BETH ANN · 2021 to 2022
$417k
NIAAA NIH HHS R00 AA025386NIAID NIH HHS R01 AI121209NIAID NIH HHS R01 AI155474NIDDK NIH HHS R01 DK125595
6 · The paper itself

Abstract

The lymphatic vasculature of the liver is vital for liver function as it maintains fluid and protein homeostasis and is important for immune cell transport to the lymph node. Chronic liver disease is associated with increased expression of inflammatory mediators including oxidized low-density lipoprotein (oxLDL). Intrahepatic levels of oxLDL are elevated in nonalcoholic fatty liver disease (NAFLD), chronic hepatitis C infection (HCV), alcohol-associated liver disease (ALD), and cholestatic liver diseases. To determine if liver lymphatic function is impaired in chronic liver diseases, in which increased oxLDL has been documented, we measured liver lymphatic function in murine models of NAFLD, ALD and primary sclerosing cholangitis (PSC). We found that

Indexed as

alcohol-associated liver diseasecholestasisliver sinusoidal endothelial celllymphatic endothelial cellnon-alcoholic fatty liver diseaseoxidized low density lipoproteinvascular endothelial growth factorVE-cadherin

Identifiers

PMID36338478
PMCPMC9626955
OpenAlexW4306843400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.