Evidence map›Paper›PMID 36337877›Full record

ArticleFrontiers in cardiovascular medicine2022

COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study.

Jiri Parenica, Klara Benesova, Martin Radvan, Ondrej Sanca, Jiri Hlasensky, Petr Lokaj, Tomas Ondrus, Katerina Helanova, Petr Kala, Ladislav Dusek and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Clinical and economic benefits of seasonal COVID-19 vaccination in Germany: results from the ROUTINE-COV19 Study, September 2022 to March 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jiri ParenicaInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Klara BenesovaDepartment of Data Collection and Processing, Institute of Health Information and Statistics of the Czech Republic, Prague, Czechia.
Martin RadvanInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Ondrej SancaDepartment of Data Collection and Processing, Institute of Health Information and Statistics of the Czech Republic, Prague, Czechia.
Jiri HlasenskyInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Petr LokajInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Tomas OndrusInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Katerina HelanovaInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Petr KalaInternal and Cardiology Department, University Hospital Brno, Brno, Czechia.
Ladislav DusekDepartment of Data Collection and Processing, Institute of Health Information and Statistics of the Czech Republic, Prague, Czechia.
Jiri JarkovskyDepartment of Data Collection and Processing, Institute of Health Information and Statistics of the Czech Republic, Prague, Czechia.
Masaryk University · CZUniversity Hospital Brno · CZInstitute of Health Information and Statistics · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heart failure (HF) patients are at higher risk of severe coronavirus disease 2019 (COVID-19). The Omicron variant has many novel mutations including those in the spike protein, leading to questions about vaccine effectiveness. The aim of this analysis was to evaluate the effectiveness of the COVID-19 vaccine with or without a booster (i.e., after the third dose) during the Omicron variant wave. Methods: Chronic heart failure patients in the Czech Republic were included in the analysis. COVID-19 infection was monitored from January 1st 2022 to March 31st 2022. The analysis was conducted on data collected in the National Health Information System. Vaccine effectiveness of vaccinated (with or without booster) vs. unvaccinated patients was analyzed for incidence of COVID-19, COVID-19-related hospitalizations, COVID-19 related intensive care unit admissions, and COVID-19 related mechanical ventilation/extracorporeal membrane oxygenation treatment. Findings: From a total 165,453 HF patients in the Czech Republic, 9,728 contracted COVID-19 (22.9% of them not vaccinated, 23.2% vaccinated and 53.8% vaccinated and boosted). Risk of intensive care unit (ICU) hospitalization was 7.6% in the unvaccinated group, 4.8% in the vaccinated group and 2.9% in the boosted group. The calculated effectiveness of the COVID-19 vaccine in prevention of ICU hospitalization in the vaccinated group was 41.9 and 76.6% in the boosted group. Interpretation: The results demonstrated moderate vaccine effectiveness in the prevention of severe COVID-19 in vaccinated but not boosted HF patients. Much stronger effectiveness was found in those who were vaccinated and boosted.

Indexed as

COVID-19heart failureOmicronsevere coursevaccination

Identifiers

PMID36337877
PMCPMC9631812
OpenAlexW4306924762

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.