Evidence map›Paper›PMID 36337662›Full record

ArticleFrontiers in nutrition2022

Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons

Lei Wang, Shigetomo Suyama, Samantha A Lee, Yoichi Ueta, Yutaka Seino, Geoffrey W G Sharp, Toshihiko Yada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Lei WangDivision of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Shigetomo SuyamaDivision of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Samantha A LeeDivision of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Yoichi UetaDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yutaka SeinoYutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Osaka, Japan.
Geoffrey W G SharpDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Toshihiko YadaDivision of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Cornell University · USGifu University · JPJichi Medical University · JPKansai Electric Power (Japan) · JPKobe University · JPUniversity of Manitoba · CAUniversity of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fasting with varying intensities is used to treat obesity-related diseases. Re-feeding after fasting exhibits hyperphagia and often rebound weight gain. However, the mechanisms underlying the hyperphagia and rebound remain elusive. Here we show that 24 h food restriction (24 h FR) and milder 50% FR, both depress synaptic transmission in the hypothalamic paraventricular nucleus (PVN) and induce acute hyperphagia in rats. 24 h FR is followed by weight rebound but 50% FR is not. Orexigenic neuropeptide Y (NPY)

Indexed as

food restrictionhysteresisneuropeptide Yoxytocinparaventricular nucleusreboundsynaptic plasticityY1 receptor

Identifiers

PMID36337662
PMCPMC9627337
OpenAlexW4306842270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.