ArticleFrontiers in nutrition2022
Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 5 citations in OpenAlex.
- Clinical characteristics of the reduced bone mineral density subgroup among adults with type 2 diabetes mellitus: a retrospective cross-sectional study.BMC musculoskeletal disorders · 2026Article
- Serum CTRP3 and CysC correlate with glucose, lipid, and bone metabolism in elderly patients with type 2 diabetes mellitus complicated with osteoporosis.Journal of diabetes investigation · 2026Article
- Smoking shapes the relationship between metabolic biomarkers and femoral-neck bone mineral density: A stratified analysis by smoking status.Tobacco induced diseases · 2026Article
- Association of serum urea-to-creatinine and creatinine-to-cystatin C ratios with bone mineral density and osteoporosis: a cross-sectional study.Scientific reports · 2025Article
- Weight-adjusted waist index is associated with risk of poor bone quality rather than low bone mass in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Cystatin C is associated with osteoporosis and fractures: An observational study based on Mendelian randomization analysis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Observational
- Association between the ratio of serum creatinine to cystatin C and bone mineral density in middle-aged and older adults: a cross-sectional study from NHANES database.The Journal of international medical research · 2023Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM). Method: This cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured. Results: Pearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS ( Conclusion: In older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.
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