Evidence map›Paper›PMID 36337316›Full record

ArticleWorld journal of clinical oncology2022

Somatic mutations in FAT cadherin family members constitute an underrecognized subtype of colorectal adenocarcinoma with unique clinicopathologic features.

Liang-Li Wang, Wei Zheng, Xiu-Li Liu, Feng Yin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Liang-Li WangDepartment of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, United States.
Wei ZhengDepartment of Pathology, Emory University School of Medicine, Atlanta, GA 30322, United States.
Xiu-Li LiuDepartment of Pathology and Immunology, Washington University, St. Louis, MO 63110, United States.
Feng YinDepartment of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, United States. fengyin@health.missouri.edu.
Emory University · USUniversity of Missouri · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe FAT cadherin family members (FAT1, FAT2, FAT3 and FAT4) are conserved tumor suppressors that are recurrently mutated in several types of human cancers, including colorectal carcinoma (CRC).

aimTo characterize the clinicopathologic features of CRC patients with somatic mutations in FAT cadherin family members.

methodsWe analyzed 526 CRC cases from The Cancer Genome Atlas PanCancer Atlas dataset. CRC samples were subclassified into 2 groups based on the presence or absence of somatic mutations in

resultsThis CRC study cohort had frequent mutations in the

conclusion

Indexed as

Clinicopathologic featuresColorectal adenocarcinomaFAT cadherin family genesPrognosisThe Cancer Genome Atlas

Identifiers

PMID36337316
PMCPMC9630991
OpenAlexW4306784564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.