ReviewEuropean heart journal2023
Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications.
Review in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The prognostic impact of prevailing definitions of periprocedural myocardial infarction in patients undergoing coronary artery bypass grafting.European heart journal. Quality of care & clinical outcomes · 2025Pooled it
- Combined Antegrade-Retrograde Cardioplegia for Myocardial Protection During Coronary Artery Bypass Grafting in Patients with Left Main Coronary Artery Disease: The CARDIOPROTECT-LMCAD Randomised Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- Benign emergence of pathological Q waves following minimally invasive direct coronary artery bypass surgery: a case series.Journal of surgical case reports · 2026Article
- Using CK-MB and hs-cTnT to Predict 30-Day Mortality After CABG: A Combined Biomarker Risk-Stratification Approach.JACC. Advances · 2026Article
- Effects of Pulsatile and Non-Pulsatile Cardiopulmonary Bypass on Early Inflammatory Response After Cardiac Surgery: A Secondary Biomarker Analysis of a Multicentric Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Cardiac Troponin I (cTnI) Dynamics After Lung Transplantation and Its Consequences for Early Postoperative Management.Clinical transplantation · 2026Article
- Comparison of Cardiac Troponin T and I: Impact on Definitions of Perioperative Myocardial Infarction After Coronary Artery Bypass Grafting.Journal of the American Heart Association · 2026Article
- Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2026Observational
- Periprocedural Myocardial Infarction: Do We Need an Updated Definition?Journal of cardiovascular development and disease · 2026Review
- High-Sensitivity Cardiac Troponin I and Mortality Following Off-Pump and On-Pump Coronary Artery Bypass Surgery: A Secondary Analysis of the Vision Cardiac Surgery Study.Interdisciplinary cardiovascular and thoracic surgery · 2026Observational
- Article
- Electrocardiogram-Alterations and Increasing Cardiac Enzymes After Coronary Artery Bypass Grafting-When Can We Expect Significant Findings in Coronary Angiography?Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Periprocedural Myocardial Infarction After Coronary Artery Bypass Grafting: Current Clinical Practices and Future Perspectives.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Unplanned Postoperative Angiography After Isolated Coronary Artery Bypass Grafting: State of the Art and Future Perspective.Medicina (Kaunas, Lithuania) · 2025Review
- Review
- Meta-Analytic Review of Coronary Angiography in Peri-Procedural Myocardial Injury and Infarction After Cardiac Surgery.Journal of clinical medicine · 2025Article
- Recent clinical research on the value of high-sensitivity cardiac troponin levels in prognostic evaluation after coronary artery bypass graft surgery: a narrative review.Cardiovascular diagnosis and therapy · 2025Review
- Occurrence of sarcopenia in elderly patients with coronary heart disease and its association with short-term prognosis.BMC cardiovascular disorders · 2025Article
- Impact of sarcopenia on ventricular remodelling following coronary artery bypass grafting in elderly patients with coronary heart disease.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 5 countries.
Funding
Abstract
The use of biomarkers is undisputed in the diagnosis of primary myocardial infarction (MI), but their value for identifying MI is less well studied in the postoperative phase following coronary artery bypass grafting (CABG). To identify patients with periprocedural MI (PMI), several conflicting definitions of PMI have been proposed, relying either on cardiac troponin (cTn) or the MB isoenzyme of creatine kinase, with or without supporting evidence of ischaemia. However, CABG inherently induces the release of cardiac biomarkers, as reflected by significant cTn concentrations in patients with uncomplicated postoperative courses. Still, the underlying (patho)physiological release mechanisms of cTn are incompletely understood, complicating adequate interpretation of postoperative increases in cTn concentrations. Therefore, the aim of the current review is to present these potential underlying mechanisms of cTn release in general, and following CABG in particular (Graphical Abstract). Based on these mechanisms, dissimilarities in the release of cTnI and cTnT are discussed, with potentially important implications for clinical practice. Consequently, currently proposed cTn biomarker cut-offs by the prevailing definitions of PMI might warrant re-assessment, with differentiation in cut-offs for the separate available assays and surgical strategies. To resolve these issues, future prospective studies are warranted to determine the prognostic influence of biomarker release in general and PMI in particular.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.