Evidence map›Paper›PMID 36336962›Full record

ArticleCancer communications (London, England)2023

Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis.

Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M Lien, Junjie Chen and 1 more

Abstract readLetter
In one paragraph

Article in Cancer communications (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shengzhe ZhangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.ORCID https://orcid.org/0000-0001-7031-4222
Sung Ho LeeDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Litong NieDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yuanjian HuangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Gengyi ZouDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Youn-Sang JungDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Sohee JunDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jie ZhangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Esther M LienDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Junjie ChenDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jae-Il ParkDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
PAF-Remodeled DREAM Complex in Cancer and RegenerationR01CA193297 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2015 to 2024
$3.6M
Modeling Esophageal Squamous Cell Cancer InitiationR03CA256207 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2021 to 2022
$162k
Cancer Prevention and Research Institute of Texas RP200315NCI NIH HHS CA193297NCI NIH HHS CA256207NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA193297NCI NIH HHS R03 CA256207Specialized Program of Research Excellence (SPORE) P50 CA83639
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Signal TransductionTOR Serine-Threonine KinasesCarcinogenesisGuanine Nucleotide Exchange FactorsHumansLysosomesMembrane ProteinsGuanine Nucleotide Exchange FactorsLAMTOR4 protein, humanMembrane ProteinsMTOR protein, humanTMEM9 protein, humanTOR Serine-Threonine Kinases

Identifiers

PMID36336962
PMCPMC9859727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.