Evidence map›Paper›PMID 36336816›Full record

ArticleJournal of neurochemistry2023

Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.

Peter J Vollbrecht, Kathryn M Nesbitt, Victoria M Addis, Keenan M Boulnemour, Daniel A Micheli, Kendall B Smith, Darleen A Sandoval, Robert T Kennedy, Carrie R Ferrario

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Peter J VollbrechtDepartment of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.ORCID 0000-0003-4677-3132
Kathryn M NesbittDepartment of Chemistry, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Victoria M AddisDepartment of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
Keenan M BoulnemourDepartment of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
Daniel A MicheliDepartment of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
Kendall B SmithDepartment of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
Darleen A SandovalDepartment of Pediatrics, School of Medicine, University of Colorado, Anshutz Medical Campus, Aurora, Colorado, USA.
Robert T KennedyDepartment of Chemistry, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Carrie R FerrarioDepartment of Pharmacology, Psychology Department (Biopsychology) University of Michigan, Ann Arbor, Michigan, USA.
Western Michigan University · USUniversity of Michigan · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
Mechanisms of Post-Bariatric HypoglycemiaR01DK121995 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATTI, MARY E, SANDOVAL, DARLEEN A. · 2019 to 2022
$2.8M
In vivo chemical monitoring using capillary separationsR01EB003320 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KENNEDY, ROBERT T · 2003 to 2020
$2.7M
Alterations in Motivated Behavior in Rodent Models of ObesityR01DK106188 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FERRARIO, CARRIE · 2015 to 2019
$1.9M
Effects of insulin on NAc excitatory transmission and motivation for foodR01DK115526 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FERRARIO, CARRIE · 2018 to 2020
$1.3M
NIBIB NIH HHS R01 EB003320NIDA NIH HHS T32 DA007268NIDDK NIH HHS DK10782NIDDK NIH HHS DK121995NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK106188NIDDK NIH HHS R01DK106188NIDDK NIH HHS R01 DK115526NIDDK NIH HHS R01DK115526-01NIDDK NIH HHS R01 DK121995NIH HHS R01EB003320NIH HHS T32DA007268
6 · The paper itself

Abstract

Obesity is one of the leading health concerns in the United States. Studies from human and rodent models suggest that inherent differences in the function of brain motivation centers, including the nucleus accumbens (NAc), contribute to overeating and thus obesity. For example, there are basal enhancements in the excitability of NAc GABAergic medium spiny neurons (MSN) and reductions in basal expression of AMPA-type glutamate receptors in obesity-prone vs obesity-resistant rats. However, very little is known about the regulation of extracellular glutamate and GABA within the NAc of these models. Here we gave obesity-prone and obesity-resistant rats stable isotope-labeled glucose (

Indexed as

Glutamic AcidNucleus AccumbensAnimalsgamma-Aminobutyric AcidGlucoseGlutamate-Ammonia LigaseGlutamineHumansObesityRatsgamma-Aminobutyric AcidGlucoseGlutamate-Ammonia LigaseGlutamic AcidGlutamine

Identifiers

PMID36336816
PMCPMC10604761
OpenAlexW4308320639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.