Evidence map›Paper›PMID 36336687›Full record

ReviewJournal of medical case reports2022

Iatrogenic Kaposi sarcoma of the small bowel in Crohn's disease following short-term use of immunomodulators: a case report and review of the literature.

Pei-Jui Wu, Chi-Shu Sun, Hsing-Tao Kuo, Ming-Jen Sheu, Cheng-Yi Lin, Su-Hung Wang, Chun-Chi Yang, Chi-Hsing Chen, Shih-Sung Chuang, I-Che Feng

Open access · goldAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of medical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pei-Jui Wu *Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Chi-Shu Sun *Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Hsing-Tao KuoDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Ming-Jen SheuDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Cheng-Yi LinDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Su-Hung WangDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Chun-Chi YangDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Chi-Hsing ChenDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC.
Shih-Sung ChuangDepartment of Pathology, Chi Mei Medical Center, Tainan, Taiwan, ROC.
I-Che FengDivision of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist., Tainan City, 71004, Taiwan, ROC. erik.feng@msa.hinet.net.
Chi Mei Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKaposi sarcoma is a vascular tumor highly related to human herpesvirus-8 and Kaposi sarcoma-associated herpesvirus. Kaposi sarcoma usually manifests as skin or mucosal lesions; involvement in visceral organs such as the gastrointestinal tract is rare. Kaposi sarcoma can occur in immunocompromised patients receiving immunosuppressive therapy, in which case it is known as iatrogenic Kaposi sarcoma or drug-induced Kaposi sarcoma. Intestinal Kaposi sarcoma in patients with inflammatory bowel disease is extremely rare. CASE PRESENTATION: A 46-year-old East Asian male with recently diagnosed Crohn's disease was administered azathioprine and prednisolone; however, the patient complained of persistent abdominal pain and diarrhea following treatment. Endoscopy revealed small bowel Kaposi sarcoma. The patient was treated with systemic chemotherapy successfully without relapse.

conclusionsThis is the fifth case of Kaposi sarcoma developed over the small intestine in a patient with Crohn's disease following administration of immunomodulators. Additionally, this case indicated that even short-term immunomodulator use can induce Kaposi sarcoma in patients with inflammatory bowel disease. Thus, in patients with inflammatory bowel disease, if symptoms are aggravated or do not abate after immunomodulators prescription, and before intending to upgrade immunomodulators, endoscopy should be considered. Finally, chemotherapy can also be considered if both medication withdrawal and surgical intervention are not feasible.

Indexed as

Crohn DiseaseHerpesvirus 8, HumanInflammatory Bowel DiseasesSarcoma, KaposiAdjuvants, ImmunologicHumansIatrogenic DiseaseImmunologic FactorsIntestine, SmallMaleMiddle AgedNeoplasm Recurrence, LocalAdjuvants, ImmunologicImmunologic FactorsChemotherapyCrohn’s diseaseGastrointestinal Kaposi sarcomaImmunomodulatorKaposi sarcoma

Identifiers

PMID36336687
PMCPMC9639291
OpenAlexW4308298552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.