Evidence map›Paper›PMID 36336684›Full record

Trial reportBMC gastroenterology2022

Association between hepatic steatosis and fibrosis with measures of insulin sensitivity in patients with severe obesity and type 2 diabetes - a cross-sectional study.

Kathrine Aglen Seeberg, Dag Hofsø, Heidi Borgeraas, John Olav Grimnes, Farhat Fatima, Lars Thomas Seeberg, Nils Petter Kvan, Marius Svanevik, Jens Kristoffer Hertel, Jøran Hjelmesæth

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01778738 (Glycaemia, Insulin Secretion and Action in Morbidly Obese Subjects With Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01778738 nacompletednot on this map

Glycaemia, Insulin Secretion and Action in Morbidly Obese Subjects With Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study

TypeinterventionalSponsorSykehuset i Vestfold HFRan2013 to 2022Enrolled125ConditionsType 2 Diabetes, Morbid ObesityArmsBariatric surgery, either gastric bypass surgery or sleeve gastrectomy, Sleeve gastrecomy, Bastric bypass
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. ISIFrontiers in medicine · 2025
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kathrine Aglen SeebergMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway. uxseek@siv.no.
Dag HofsøMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
Heidi BorgeraasMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
John Olav GrimnesDepartment of Radiology, Vestfold Hospital Trust, Tønsberg, Norway.
Farhat FatimaMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
Lars Thomas SeebergDepartment of Surgery, Vestfold Hospital Trust, Tønsberg, Norway.
Nils Petter KvanDepartment of Radiology, Vestfold Hospital Trust, Tønsberg, Norway.
Marius SvanevikMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
Jens Kristoffer HertelMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
Jøran HjelmesæthMorbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
Sykehuset i Vestfold · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity, non-alcoholic fatty liver disease (NAFLD) and insulin resistance are three pathological conditions highly correlated, but this relationship is not fully elucidated. Hence, we aimed to assess the association of hepatic steatosis and fibrosis with different measures of insulin sensitivity in patients with severe obesity and type 2 diabetes mellitus (T2DM).

methodsA cross-sectional study (Oseberg trial) including patients with T2DM referred for bariatric surgery at Vestfold Hospital Trust, Norway. Magnetic resonance imaging (MRI) and the enhanced liver fibrosis (ELF) test was used for estimation of liver fat fraction (LFF) and degree of fibrosis, respectively. Oral and intravenous glucose tolerance tests were applied for estimation of insulin sensitivity (HOMA2S, Matsuda ISI and MinMod SI).

resultsA total of 100 patients (mean [SD] age 47.5 [9.7] years, 65% women, BMI 42.0 [5.3] kg/m

conclusionsPatients with morbid obesity and T2DM demonstrated high levels of liver fat fraction, and we showed that hepatic steatosis, but not the degree of liver fibrosis, was associated with different measures of insulin sensitivity in patients with severe obesity and T2DM. Further, our results might indicate that the LFF is primarily associated with hepatic, and not peripheral insulin sensitivity. To improve the diagnosis of NAFLD and the prediction of its progression, more studies are needed to reveal the pathological mechanistic pathways involved in NAFLD and insulin sensitivity.

trial registrationClinicalTrials.gov: NCT01778738.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceNon-alcoholic Fatty Liver DiseaseObesity, MorbidAdultCross-Sectional StudiesFemaleHumansLiverLiver CirrhosisMaleMiddle AgedELF testHepatic steatosisInsulin sensitivityLiver fat fractionLiver fibrosisSevere obesityType 2 diabetes mellitus

Identifiers

PMID36336684
PMCPMC9639281
OpenAlexW4308299776

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.