Evidence map›Paper›PMID 36336304›Full record

ReviewThe international journal of biochemistry & cell biology2022

How sticky? How tight? How hot? Imaging probes for fluid viscosity, membrane tension and temperature measurements at the cellular level.

Matthew Pittman, Abdulla M Ali, Yun Chen

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The international journal of biochemistry & cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew PittmanDepartment of Mechanical Engineering, Johns Hopkins University, MD, USA; Center for Cell Dynamics, Johns Hopkins University, MD, USA; Institute for NanoBio Technology, Johns Hopkins University, MD, USA.
Abdulla M AliCenter for Cell Dynamics, Johns Hopkins University, MD, USA; Institute for NanoBio Technology, Johns Hopkins University, MD, USA; T.C. Jenkins Department of Biophysics, Johns Hopkins University, MD, USA.
Yun ChenDepartment of Mechanical Engineering, Johns Hopkins University, MD, USA; Center for Cell Dynamics, Johns Hopkins University, MD, USA; Institute for NanoBio Technology, Johns Hopkins University, MD, USA. Electronic address: yun.chen@jhu.edu.
Johns Hopkins University · US

Funding

Tension-Sensitive Drug Release System to Enhance Targeting SelectivityR21EB029677 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CHEN, YUN · 2020 to 2020
$610k
High-Throughput, Multiplexing-Ready Intracellular Pressure ProbesR21GM146105 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CHEN, YUN, LIN, CHENXIANG · 2022 to 2023
$465k
Exploring the effects of extracellular fluid viscosity on cell migration and cancer metastasisF31HL154709 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PITTMAN, MATTHEW · 2020 to 2021
$89k
NHLBI NIH HHS F31 HL154709NIBIB NIH HHS R21 EB029677NIGMS NIH HHS R21 GM146105
6 · The paper itself

Abstract

We review the progress made in imaging probes for three important physical parameters: viscosity, membrane tension, and temperature, all of which play important roles in many cellular processes. Recent evidences showed that cell migration speed can be modulated by extracellular fluid viscosity; membrane tension contributes to the regulation of cell motility, exo-/endo-cytosis, and cell spread area; and temperature affects neural activity and adipocyte differentiation. We discuss the techniques implementing imaging-based probes to measure viscosity, membrane tension, and temperature at subcellular resolution dynamically. The merits and shortcomings of each technique are examined, and the future applications of the recently developed techniques are also explored.

Indexed as

ViscosityCell MembraneTemperatureIntracellular, imaging probesTemperatureTensionViscosity

Identifiers

PMID36336304
PMCPMC10148659
OpenAlexW4308364410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.