Evidence map›Paper›PMID 36335817›Full record

ArticleOral oncology2022

Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions.

David R Brenes, Allison J Nipper, Melody T Tan, Frederico O Gleber-Netto, Richard A Schwarz, Curtis R Pickering, Michelle D Williams, Nadarajah Vigneswaran, Ann M Gillenwater, Andrew G Sikora and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

David R BrenesRice University, Department of Bioengineering MS-142, 6100 Main St., Houston, TX 77005, USA. Electronic address: drb12@rice.edu.
Allison J NipperThe University of Texas MD Anderson Cancer Center, Department of Head & Neck Surgery, 1400 Pressler Street, Houston, TX 77030, USA.
Melody T TanRice University, Department of Bioengineering MS-142, 6100 Main St., Houston, TX 77005, USA.
Frederico O Gleber-NettoThe University of Texas MD Anderson Cancer Center, Department of Head & Neck Surgery, 1400 Pressler Street, Houston, TX 77030, USA.
Richard A SchwarzRice University, Department of Bioengineering MS-142, 6100 Main St., Houston, TX 77005, USA.
Curtis R PickeringThe University of Texas MD Anderson Cancer Center, Department of Head & Neck Surgery, 1400 Pressler Street, Houston, TX 77030, USA.
Michelle D WilliamsThe University of Texas MD Anderson Cancer Center, Department of Anatomical Pathology, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Nadarajah VigneswaranThe University of Texas Health School of Dentistry, Department of Diagnostic and Biomedical Sciences, 7500 Cambridge St., Houston, TX 77054, USA.
Ann M GillenwaterThe University of Texas MD Anderson Cancer Center, Department of Head & Neck Surgery, 1400 Pressler Street, Houston, TX 77030, USA.
Andrew G SikoraThe University of Texas MD Anderson Cancer Center, Department of Head & Neck Surgery, 1400 Pressler Street, Houston, TX 77030, USA.
Rebecca R Richards-KortumRice University, Department of Bioengineering MS-142, 6100 Main St., Houston, TX 77005, USA.
The University of Texas MD Anderson Cancer Center · USRice University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Targeting the immunosuppressive tumor microenvironment to enhance efficacy of radiotherapy and immuno-radiotherapy for oral cancerU01DE028233 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANNAPRAGADA, ANANTH V, SIKORA, ANDREW · 2018 to 2022
$3.9M
Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of CancerR01DE029590 · NIDCR · RICE UNIVERSITY · PI GILLENWATER, ANN M, RICHARDS-KORTUM, REBECCA R. · 2020 to 2024
$3.2M
NCI NIH HHS P30 CA016672NIDCR NIH HHS R01 DE029590NIDCR NIH HHS U01 DE028233
6 · The paper itself

Abstract

objectiveOptical imaging studies of oral premalignant lesions have shown that optical markers, including loss of autofluorescence and altered morphology of epithelial cell nuclei, are predictive of high-grade pathology. While these optical markers are consistently positive in lesions with moderate/severe dysplasia or cancer, they are positive only in a subset of lesions with mild dysplasia. This study compared the gene expression profiles of lesions with mild dysplasia (stratified by optical marker status) to lesions with severe dysplasia and without dysplasia. MATERIALS AND

methodsForty oral lesions imaged in patients undergoing oral surgery were analyzed: nine without dysplasia, nine with severe dysplasia, and 22 with mild dysplasia. Samples were submitted for high throughput gene expression analysis.

resultsThe analysis revealed 116 genes differentially expressed among sites without dysplasia and sites with severe dysplasia; 50 were correlated with an optical marker quantifying altered nuclear morphology. Ten of 11 sites with mild dysplasia and positive optical markers (91%) had gene expression similar to sites with severe dysplasia. Nine of 11 sites with mild dysplasia and negative optical markers (82%) had similar gene expression as sites without dysplasia.

conclusionThis study suggests that optical imaging may help identify patients with mild dysplasia who require more intensive clinical follow-up. If validated, this would represent a significant advance in patient care for patients with oral premalignant lesions.

Indexed as

Mouth MucosaPrecancerous ConditionsCell NucleusHumansHyperplasiaOptical ImagingDysplasiaGene expression analysisOptical imagingOral cancerOral lesion

Identifiers

PMID36335817
PMCPMC9881670
OpenAlexW4308347506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.