SynthesisClinical cardiology2022
The efficacy of nitroglycerin to prevent radial artery spasm and occlusion during and after transradial catheterization: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05626660 (Comparison Between Right and Left Radial Approach in Patients Undergoing Percutaneous Coronary Procedures), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Between Right and Left Radial Approach in Patients Undergoing Percutaneous Coronary Procedures
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Protamine sulphate for heparin reversal in percutaneous cardiac interventions: a systematic review and meta-analysis of randomized controlled trials.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Virtual Reality Distraction for Reducing Pain and Anxiety During Percutaneous Cardiovascular Interventions: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Local nitroglycerin to facilitate radial arterial catheterization in adults: a systematic review and meta-analysis.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Pooled it
- Transradial artery access for carotid artery stenting: A pooled analysis.The neuroradiology journal · 2024Pooled it
- The efficacy of nitroglycerin to prevent radial artery spasm and occlusion during and after transradial catheterization: A systematic review and meta-analysis of randomized controlled trials.Clinical cardiology · 2022Pooled it
- Comparing Two Distal Radial Hemostatic Devices for Radial Artery Patency Post-TACE: A Randomized Trial.Cardiovascular and interventional radiology · 2026Trial
- Sedation Strategy, Procedural Comfort, and Clinically Detected Radial Artery Spasm During Transradial Coronary Angiography: A Prospective Observational Study.Journal of clinical medicine · 2026Article
- Evidence summary of nursing care of arterial drug administration and catheter management for HAIC in hepatocellular carcinoma.Medicine · 2026Article
- Percutaneous Coronary Intervention and vascular access complications: A contemporary review.NPJ cardiovascular health · 2026Review
- Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography (PASS): rationale and design.Stroke and vascular neurology · 2026Article
- Precision percutaneous coronary intervention.NPJ cardiovascular health · 2026Review
- Direct oral anticoagulants are effective in preventing but not resolving radial artery occlusion: a systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Review
- Bicentric clinical study: Feasibility of 088 long sheath in trans-radial carotid artery stenting.Neurosurgical review · 2025Article
- Non-fasting versus fasting before percutaneous cardiac procedures: a systematic review and meta-analysis of randomized controlled trials.Perioperative medicine (London, England) · 2025Review
- Periprocedural Use of Heparin and Other Factors Contributing to the Patency of the Radial Artery Following Diagnostic Coronary Angiography.Journal of clinical medicine · 2025Article
- Evaluation of Subcutaneous Puncture Site Cocktails for Distal Transradial Cerebral Angiography in Improving Puncture Success and Cannulation-Induced Vasospasm: A Single-Center Retrospective Study.Journal of neuroendovascular therapy · 2025Article
- Nitroglycerin (NTG) Infusion for Intraprocedural Vasospasm in Transarterial Microembolization (TAME): A Case Series.Life (Basel, Switzerland) · 2024Article
- Efficacy of brachial plexus block in reducing radial artery spasm during interventional aneurysm surgery.iScience · 2024Article
- Radial Artery Spasm-A Review on Incidence, Prevention and Treatment.Diagnostics (Basel, Switzerland) · 2024Review
- Incidence and Prognostic Factors of Radial Artery Occlusion in Transradial Coronary Catheterization.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radial artery spasm (RAS) is the most common cause of transradial access site crossover and is a common intra-procedural complication. RAS incidence can lead to radial artery occlusion (RAO) postprocedure, preventing the radial artery as a future access site. We evaluated the efficacy of nitroglycerin preventing RAS and RAO during transradial catheterization discussing the different routes of administration, including topical, subcutaneous, and intra-arterial. A systematic review and meta-analysis included all relevant articles until April 23, 2022. We searched six databases Google Scholar, Web of Science, SCOPUS, EMBASE, PubMed (MEDLINE), and CENTRAL. We registered our review protocol in PROSPERO with ID: CRD42022330356. We included 11 trials with 5814 patients. Compared to placebo, the pooled analysis favored subcutaneous nitroglycerin in preventing RAS (risk ratio [RR]: 0.57 with 95% confidence interval [CI] [0.43-0.77], p = .0003) and RAO (RR: 0.39 with 95% CI [0.16-0.98], p = .05). In contrast to the intra-arterial nitroglycerin that showed nonstatistically significant results in preventing RAS and RAO (RR: 0.8 with 95% CI [0.63-1.02], p = .07)- (RR: 0.78 with 95% CI [0.6-1.01], p = .06)), respectively. Also, topical nitroglycerin did not prevent RAS (RR: 0.73 with 95% CI [0.42-1.24], p = .24). Compared with placebo, subcutaneous nitroglycerin during transradial catheterization reduced the incidence of RAS and RAO. Meanwhile, Intra-arterial and topical nitroglycerin did not show statistically significant outcomes. Subcutaneous nitroglycerin may be a practical and cost-effective technique to facilitate transradial catheterization; however, more RCTs are needed to evaluate the subcutaneous versus intra-arterial nitroglycerin administration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.