Evidence map›Paper›PMID 36335596›Full record

ArticleBioconjugate chemistry2022

Rapid Electrophilic Cysteine Arylation with Pyridinium Salts.

Bradley M Lipka, Vincent M Betti, Daniel S Honeycutt, Daniel L Zelmanovich, Max Adamczyk, Ruojun Wu, Harrison S Blume, Caitlin A Mendina, Jacob M Goldberg, Fang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Ultra-rapid Electrophilic Cysteine Arylation.Journal of the American Chemical Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bradley M LipkaDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island02881, United States.
Vincent M BettiDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, New York13346, United States.ORCID 0000-0003-0124-6793
Daniel S HoneycuttDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island02881, United States.ORCID 0000-0001-6143-4492
Daniel L ZelmanovichDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, New York13346, United States.
Max AdamczykDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island02881, United States.
Ruojun WuDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, New York13346, United States.ORCID 0000-0003-0097-6698
Harrison S BlumeDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, New York13346, United States.ORCID 0000-0003-0557-7821
Caitlin A MendinaDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, New York13346, United States.
Jacob M GoldbergDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, New York13346, United States.ORCID 0000-0002-8004-3769
Fang WangDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island02881, United States.ORCID 0000-0002-9192-6858

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Christopher Lee Hemme · 2012 to 2026
$63.6M
NIGMS NIH HHS P20 GM103430
6 · The paper itself

Abstract

Here, we present a series of fluorinated cationic reagents that enable rapid arylation of cysteine under mild conditions compatible with proteins and peptides. The highly polarized C-F bond and attractive nucleophile-electrophile Coulombic interactions substantially accelerate cysteine arylation, leading to unusually high rate constants on the order of 100 M

Indexed as

CysteineSaltsIndicators and ReagentsPeptidesProteinsCysteineIndicators and ReagentsPeptidesProteinsSalts

Identifiers

PMID36335596
PMCPMC13011920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.