Evidence map›Paper›PMID 36335569›Full record

ArticleDevelopmental medicine and child neurology2023

Mammillary body abnormalities and cognitive outcomes in children cooled for neonatal encephalopathy.

Arthur P C Spencer, Maarten H Lequin, Linda S de Vries, Jonathan C W Brooks, Sally Jary, James Tonks, Frances M Cowan, Marianne Thoresen, Ela Chakkarapani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental medicine and child neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Arthur P C SpencerTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-7869-6261
Maarten H LequinDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, the Netherlands.
Linda S de VriesDepartment of Neonatology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-7282-8304
Jonathan C W BrooksClinical Research and Imaging Centre, University of Bristol, Bristol, UK.ORCID 0000-0003-3335-6209
Sally JaryTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0003-1335-1726
James TonksTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Frances M CowanTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Marianne ThoresenTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-9615-9109
Ela ChakkarapaniTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
University of Bristol · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity Medical Center Utrecht · NLUniversity of East Anglia · GBUniversity of Exeter · GBUniversity of Oslo · NOUtrecht University · NL

Funding

Medical Research Council MR/N026969/1Wellcome TrustWellcome Trust WT220070/Z/20/Z
6 · The paper itself

Abstract

aimTo evaluate mammillary body abnormalities in school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy (cases) and matched controls, and associations with cognitive outcome, hippocampal volume, and diffusivity in the mammillothalamic tract (MTT) and fornix.

methodMammillary body abnormalities were scored from T1-weighted magnetic resonance imaging (MRI) in 32 cases and 35 controls (median age [interquartile range] 7 years [6 years 7 months-7 years 7 months] and 7 years 4 months [6 years 7 months-7 years 7 months] respectively). Cognition was assessed using the Wechsler Intelligence Scale for Children, Fourth Edition. Hippocampal volume (normalized by total brain volume) was measured from T1-weighted MRI. Radial diffusivity and fractional anisotropy were measured in the MTT and fornix, from diffusion-weighted MRI using deterministic tractography.

resultsMore cases than controls had mammillary body abnormalities (34% vs 0%; p < 0.001). Cases with abnormal mammillary bodies had lower processing speed (p = 0.016) and full-scale IQ (p = 0.028) than cases without abnormal mammillary bodies, and lower scores than controls in all cognitive domains (p < 0.05). Cases with abnormal mammillary bodies had smaller hippocampi (left p = 0.016; right p = 0.004) and increased radial diffusivity in the right MTT (p = 0.004) compared with cases without mammillary body abnormalities.

interpretationCooled children with mammillary body abnormalities at school-age have reduced cognitive scores, smaller hippocampi, and altered MTT microstructure compared with those without mammillary body abnormalities, and matched controls. WHAT THIS PAPER ADDS: Cooled children are at higher risk of mammillary body abnormalities than controls. Abnormal mammillary bodies are associated with reduced cognitive scores and smaller hippocampi. Abnormal mammillary bodies are associated with altered mammillothalamic tract diffusivity.

Indexed as

Brain DiseasesInfant, Newborn, DiseasesChildCognitionDiffusion Magnetic Resonance ImagingFornix, BrainHumansInfantInfant, NewbornMagnetic Resonance ImagingMammillary Bodies

Identifiers

PMID36335569
PMCPMC10952753
OpenAlexW4308294765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.