Evidence map›Paper›PMID 36335388›Full record

ArticleBMC research notes2022

Hospital-prepared low-dose atropine eye drops for myopia progression control using atropine sulfate injection diluted in normal saline and lubricants.

Nuthida Wongwirawat, Nirachorn Kuchonthara, Sorrawit Boontanomwong, Krit Pongpirul

Abstract read
In one paragraph

Article in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nuthida WongwirawatEye Center, Bumrungrad International Hospital, Bangkok, 10110, Thailand.
Nirachorn KuchontharaPharmaceutical Admixture and Compounding Services, Bumrungrad International Hospital, Bangkok, 10110, Thailand.
Sorrawit BoontanomwongPharmaceutical Admixture and Compounding Services, Bumrungrad International Hospital, Bangkok, 10110, Thailand.
Krit PongpirulClinical Research Center, Bumrungrad International Hospital, Bangkok, 10110, Thailand. doctorkrit@gmail.com.ORCID http://orcid.org/0000-0003-3818-9761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAs low-dose atropine eye-drops for myopia progression control prepared in-house by diluting the commercial 0.1% atropine eye-drop with sterile water or normal saline has been a common practice whereas atropine injection is readily available and could be a more feasible alternative, this study aimed to assess the properties of the in-house low-dose atropine eye-drops prepared by diluting the atropine injection in two solvents and tested in two temperature conditions.

resultsThe 0.01% atropine eye-drops contains no bacteria, fungi, or particulate matter. The levels of atropine sulfate on all samples were comparable to the freshly prepared samples at the 12th week, regardless of the solvents used or storage conditions. The low-dose atropine eye-drops prepared from readily available atropine sulfate injection at healthcare facilities could be an alternative to commercial products.

Indexed as

AtropineMyopiaHospitalsHumansLubricantsMydriaticsOphthalmic SolutionsSaline SolutionSolventsAtropineLubricantsMydriaticsOphthalmic SolutionsSaline SolutionSolventsAtropineEyedropMyopia

Identifiers

PMID36335388
PMCPMC9636612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.