Evidence map›Paper›PMID 36335362›Full record

ArticleMicrobial cell factories2022

Engineering Cupriavidus necator H16 for enhanced lithoautotrophic poly(3-hydroxybutyrate) production from CO

Soyoung Kim, Yong Jae Jang, Gyeongtaek Gong, Sun-Mi Lee, Youngsoon Um, Kyoung Heon Kim, Ja Kyong Ko

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 46 citations in OpenAlex.

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  7. A promoter library for tuning gene expression inFrontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Soyoung KimClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Yong Jae JangClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Gyeongtaek GongClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Sun-Mi LeeClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Youngsoon UmClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Kyoung Heon KimDepartment of Biotechnology, Graduate School, Korea University, Seoul, 02841, Republic of Korea.
Ja Kyong KoClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. jkko@kist.re.kr.
Korea Institute of Science and Technology · KRKorea University of Science and Technology · KRKorea University · KR

Funding

Korea Institute of Science and Technology (KIST) Institutional Programs 2E31833Korea Institute of Science and Technology (KIST) Institutional Programs 2E31853National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) RS-2022-00156236
6 · The paper itself

Abstract

backgroundA representative hydrogen-oxidizing bacterium Cupriavidus necator H16 has attracted much attention as hosts to recycle carbon dioxide (CO

resultsHere, we engineer the carbon fixation metabolism to improve CO

conclusionsThe global transcriptional regulator RegA plays an important role in the regulation of carbon fixation and shows the possibility to improve autotrophic cell growth and PHB accumulation by increasing its expression level. This work represents another step forward in better understanding and improving the lithoautotrophic PHB production by C. necator H16.

Indexed as

Cupriavidus necator3-Hydroxybutyric AcidCarbon DioxideHydroxybutyratesPolyhydroxybutyrates3-Hydroxybutyric AcidCarbon DioxideHydroxybutyratespoly-beta-hydroxybutyratePolyhydroxybutyratesCalvin Benson Bassham (CBB) cycleCarbon dioxide fixationCupriavidus necator H16Lithoautotrophic culturePolyhydroxybutyrate (PHB)Transcriptional regulator

Identifiers

PMID36335362
PMCPMC9636797
OpenAlexW4308292305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.