Evidence map›Paper›PMID 36335297›Full record

Trial reportBMC anesthesiology2022

Comparison of the efficacy of two doses of dexmedetomidine as an adjunct to levobupivacaine in infraclavicular brachial plexus block: prospective double-blinded randomized controlled trial.

Huda F Ghazaly, Ahmed Alsaied A Aly, Zaher Zaki Zaher, Mahmoud M Hassan, Ahmed Abdelreheem Mahmoud

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04729868 nacompletednot on this map

Ultrasound Guided Infraclavicular Brachial Plexus Block Using Levo-bupivacaine Alone or Combined With Dexmedetomidine for Hand and Forearm Surgeries

TypeinterventionalSponsorAswan University HospitalRan2017 to 2020Enrolled60ConditionsAcquired Deformity of Elbow, Forearm, Hand, WristArmsLevobupivacaine(chirocaine) plus dexmedetomidine(precedex)
NCT07249827 phase2completednot on this mapstarted 2025, after this paper: background citation

A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block

TypeinterventionalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2025 to 2026Enrolled69ConditionsAnalgesia, Pain, Acute, Upper Extremity Surgery, Nerve BlockArmsdexmedetomidine (perineural) 0.67 mcg/kg, dexmedetomidine (perineural) 1 mcg/kg, dexmedetomidine (perineural) 1.33 mcg/kg
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Huda F GhazalyAnesthetic Department, Faculty of Medicine, Aswan University, Aswan, Egypt. huda.fahmy@aswu.edu.eg.
Ahmed Alsaied A AlyAnesthetic Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Zaher Zaki ZaherAnesthetic Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Mahmoud M HassanAnesthetic Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Ahmed Abdelreheem MahmoudAnesthetic Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Aswan University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis prospective, double-blind, randomized, controlled trial compared the efficacy of two dexmedetomidine doses (50 and 100-μg) combined with levobupivacaine on sensory block duration in infraclavicular brachial plexus block. We hypothesized that perineural dexmedetomidine would extend sensory block duration dose-dependently.

methodsThe study included 60 patients aged 20 to 60 years of both sex with an ASA I/II undergoing forearm and hand surgery. The patients were randomly assigned into three equal groups (n = 20) for ultrasound-guided infraclavicular brachial plexus block. The L group received 35-mL 0.5% levobupivacaine plus normal saline, the LD50 group received 35-mL 0.5% levobupivacaine plus 50-μg dexmedetomidine, and the LD100 group received 35-mL 0.5% levobupivacaine plus 100-μg dexmedetomidine. Patients were investigated for onset and duration of sensory blockade, time to first postoperative rescue analgesia, and the total 24-h postoperative morphine requirement.

resultsThe LD100 group had a longer sensory block duration (15.55 ± 1.1 h; 95% confidence interval (CI), 15.04-16.06) than the LD50 group (12.8 ± 1.2 h; 95% CI, 12.24-13.36 h) (p < 0.001) or the L group (9.95 ± 1.05 h; 95% CI, 9.46-10.44 h) (p < 0.001). The LD100 group took longer to request postoperative rescue analgesia and required fewer postoperative morphine doses than the LD50 and L groups (P < 0.001).

conclusionsSensory block duration was longer with perineural 100-μg dexmedetomidine as an adjunct to levobupivacaine than with 50-μg dexmedetomidine.

trial registrationThis study was approved by the Ethics Committee of Aswan University Hospital (approval number: aswu/125/4/17) (date of registration: 04/04/2017). Furthermore, the trial was retrospectively registered at ClinicalTrial.gov (NCT04729868) with a verification date of January 2021.

Indexed as

Brachial Plexus BlockDexmedetomidineAnesthetics, LocalHumansLevobupivacaineMorphine DerivativesProspective StudiesAnesthetics, LocalDexmedetomidineLevobupivacaineMorphine DerivativesAdjunctAnalgesiaDexmedetomidineLevobupivacaineUltrasound-guided infraclavicular block

Identifiers

PMID36335297
PMCPMC9636652
OpenAlexW4308262112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.