Evidence map›Paper›PMID 36335052›Full record

ArticleHuman immunology2023

HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 allele frequencies of North Tanzanian Maasai.

Amber Barton, Athumani Ramadhani, Elias Mafuru, Tara Mtuy, Patrick Massae, Aiweda Malissa, Tamsyn Derrick, Joanna Houghton, Anna Harte, Thomas Payne and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amber BartonClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Athumani RamadhaniEye Health Project, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Elias MafuruEye Health Project, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Tara MtuyClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK; Eye Health Project, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Patrick MassaeEye Health Project, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Aiweda MalissaEye Health Project, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Tamsyn DerrickClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK; Eye Health Project, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Joanna HoughtonClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Anna HarteClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Thomas PayneClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Harry PickeringClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Matthew J BurtonClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Chrissy H RobertsClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Martin J HollandClinical Research Department, Faculty of Infectious and Tropiclal Diseases, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: Martin.Holland@lshtm.ac.uk.

Funding

Wellcome Trust 093368Wellcome Trust 098481
6 · The paper itself

Abstract

Locus-specific amplicon sequencing was used to HLA type 336 participants of Maasai ethnicity at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci. Participants were recruited from three study villages in North Tanzania, for the purpose of investigating risk factors for trachomatous scarring in children. Other than HLA-A, all loci significantly deviated from Hardy-Weinberg equilibrium, possibly due to high relatedness between individuals: 238 individuals shared a house with at least one another participant. The most frequent allele for each locus were A*68:02 (14.3 %), B*53:01 (8.4 %), C*06:02 (19.2 %), DRB1*13:02 (17.7 %), DQB1*02:01 (16.9 %) and DPB1*01:01 (15.7 %), while the most common inferred haplotype was A*68:02 ∼ B*18:01 ∼ C*07:04 ∼ DRB1*08:04 ∼ DQB1*04:02 ∼ DPB1*04:01 (1.3 %).

Indexed as

HLA-A AntigensAllelesChildGene FrequencyHaplotypesHLA-DQ beta-ChainsHLA-DRB1 ChainsHumansTanzaniaHLA-A AntigensHLA-DQ beta-ChainsHLA-DRB1 ChainsHLAImmunogeneticsMaasaiMHCTanzania

Identifiers

PMID36335052
PMCPMC7618281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.